CABLES1
Description
The CABLES1 (Cdk5 and Abl enzyme substrate 1) is a protein-coding gene located on chromosome 18.
CABLES1, or CDK5 and ABL1 enzyme substrate 1, is a protein encoded by the CABLES1 gene. It functions as a CDK-binding protein involved in cell proliferation and/or differentiation. CABLES1 acts as a tumor suppressor gene, and its loss through mutations, knockout, knockdown, or inactivation can contribute to colorectal cancer (CRC).
CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that regulates CDK activity by enhancing tyrosine phosphorylation. It promotes CDK5 activation through ABL1, crucial for neuronal development, while decreasing CDK2 activity via WEE1, leading to growth inhibition. CABLES1 positively influences neuronal outgrowth and acts as a regulator in p53/p73-induced cell death.
CABLES1 is also known as CABL1, CABLES, HsT2563, IK3-1.
