CABIN1

Description

The CABIN1 (calcineurin binding protein 1) is a protein-coding gene located on chromosome 22.

Calcineurin-binding protein cabin-1 is a protein encoded by the CABIN1 gene in humans. It plays a vital role in the T-cell receptor-mediated signal transduction pathway by binding specifically to the activated form of calcineurin and inhibiting its function. This protein is located in the nucleus and contains a leucine zipper domain and several PEST motifs, which are sequences that target proteins for degradation. At least four alternatively spliced transcripts have been identified for this gene, but the full-length nature of most of them remains unclear. CABIN1 has been shown to interact with amphiphysin, MEF2B, MEF2D, and SIN3A.

CABIN1 may play a crucial role in replication-independent chromatin assembly. It acts as a negative regulator of T-cell receptor (TCR) signaling by inhibiting calcineurin. This inhibition of activated calcineurin is dependent on both protein kinase C (PKC) and calcium signals. Furthermore, CABIN1 serves as a negative regulator of p53/TP53 by maintaining p53 in an inactive state on chromatin at the promoters of a subset of its target genes.

CABIN1 is also known as CAIN, KB-318B8.7, PPP3IN.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing