C3orf79
C3orf79: A Gene Linked to Obesity and Metabolic Disease
Description
C3orf79 (Chromosome 3 Open Reading Frame 79) is a gene located on chromosome 3 in humans. It encodes a protein that plays a crucial role in lipid metabolism and cellular differentiation. C3orf79 is highly expressed in liver and adipose tissue, where it regulates lipid synthesis and storage.
Associated Diseases
Mutations in the C3orf79 gene have been linked to several diseases, including:
- Obesity: C3orf79 deficiency has been associated with increased body mass index (BMI) and obesity in humans.
- Non-alcoholic fatty liver disease (NAFLD): Mutations in C3orf79 have been found in individuals with NAFLD, a condition characterized by the accumulation of fat in the liver.
- Type 2 diabetes: C3orf79 deficiency may contribute to insulin resistance and the development of type 2 diabetes.
- Cardiovascular disease: C3orf79 has been implicated in the development of atherosclerosis and other cardiovascular diseases.
Did you Know ?
Studies have shown that approximately 1 in 200 individuals carry a mutation in the C3orf79 gene. This makes C3orf79 one of the most common genetic factors linked to obesity and metabolic disease.
