C3AR1
C3aR1: A Critical Receptor in Inflammation and Immune Response
Description
C3aR1 is a G protein-coupled receptor that plays a crucial role in the innate immune system. It binds to C3a, a complement protein fragment generated during the complement cascade, which is a key component of the immune response.
C3aR1 is expressed on various immune cells, including neutrophils, macrophages, and eosinophils. Upon binding of C3a, C3aR1 triggers intracellular signaling pathways that lead to the activation of these immune cells, promoting inflammation and immune responses.
Associated Diseases
Dysregulation of C3aR1 signaling has been implicated in a range of diseases, including:
- Inflammatory diseases: Rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, and inflammatory bowel disease
- Neutrophilic disorders: Autoimmune neutropenia, severe congenital neutropenia
- Infectious diseases: Sepsis, pneumonia, viral infections
- Allergic diseases: Asthma, allergic rhinitis
Did you Know ?
A study published in the journal "Nature Immunology" found that individuals with genetic variations in the C3aR1 gene were more susceptible to severe COVID-19 infections. The study suggests that C3aR1 plays a role in the inflammatory response to viral infections.
