C20orf24
c20orf24: Unraveling the Enigma of a Multifaceted Gene
Description
c20orf24 is a gene located on chromosome 20 in humans. It belongs to the ovarian cancer-associated gene family and plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and immune response.
The protein encoded by c20orf24 is known as chromosome 20 open reading frame 24 (C20orf24). It is a highly conserved protein with orthologs found across different species, suggesting its evolutionary importance.
Associated Diseases
Mutations or dysregulation of c20orf24 have been linked to several diseases, primarily:
- Ovarian cancer: c20orf24 is frequently overexpressed in ovarian cancer cells. Overexpression of this gene promotes cell proliferation, invasion, and angiogenesis, contributing to tumor growth and progression.
- Breast cancer: Studies have shown an association between increased c20orf24 expression and poor prognosis in breast cancer patients. High c20orf24 levels are associated with decreased relapse-free survival and overall survival.
- Other cancers: Dysregulation of c20orf24 has also been implicated in various other cancers, including uterine cancer, endometrial cancer, and gastric cancer, suggesting its potential role in carcinogenesis.
Did you Know ?
In a study involving 254 ovarian cancer patients, high c20orf24 expression was observed in 63% of the cases. Furthermore, patients with high c20orf24 expression had a significantly shorter overall survival compared to those with low c20orf24 expression.
