C1R
Description
The C1R (complement C1r) is a protein-coding gene located on chromosome 12.
Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the innate immune system. In humans, C1r is encoded by the C1R gene. C1r along with C1q and C1s form the C1 complex, which is the first component of the serum complement system. C1r is an enzyme that activates C1s to its active form, by proteolytic cleavage.
== Clinical significance == Ehlers–Danlos syndrome Periodontal type is associated with mutations in the CR1 gene
== Function == C1r has been shown to interact with C1s. C1r cleaves C1s to form the active form of C1s.
== References ==
== Further reading ==
== External links == Human C1R genome location and C1R gene details page in the UCSC Genome Browser.
C1r B chain is a serine protease that, along with C1q and C1s, forms the C1 complex, the first component of the classical complement pathway.
C1R is also known as EDS8, EDSPD1.
