C1QL3
Description
The C1QL3 (complement C1q like 3) is a protein-coding gene located on chromosome 10.
C1QL3 may play a role in regulating the number of excitatory synapses formed on hippocampus neurons, without affecting inhibitory synapses. It is involved in glucose homeostasis, stimulating glucose uptake in adipocytes, myotubes, and hepatocytes via the AMPK signaling pathway, and enhancing insulin-stimulated glucose uptake. In a hepatoma cell line, C1QL3 decreases de novo glucose production by reducing the expression of gluconeogenic enzymes G6PC1 and PCK1.
C1QL3 is also known as C1QTNF13, C1ql, CTRP13, K100.
Associated Diseases
- type 2 diabetes mellitus
- Potocki-Lupski syndrome
- X-linked severe congenital neutropenia
- nonimmune chronic idiopathic neutropenia of adults
- neutropenia, severe congenital, 2, autosomal dominant
- schizophrenia 15
- autosomal recessive severe congenital neutropenia due to CSF3R deficiency
- intellectual disability, autosomal dominant 50
- myeloperoxidase deficiency
- spinocerebellar ataxia type 14
- primary immunodeficiency syndrome due to p14 deficiency
- neutropenia-monocytopenia-deafness syndrome
- 22q11.2 deletion syndrome
