C1orf158
C1orf158: An Intriguing Gene with Wide-Ranging Implications
Introduction
C1orf158, also known as chromosome 1 open reading frame 158, is a gene located on chromosome 1 in humans. It encodes a protein with a yet-undetermined function, but recent research has uncovered its association with a spectrum of diseases and conditions.
Description
The C1orf158 gene comprises 13 exons and spans approximately 220 kilobases on chromosome 1. It is highly conserved across species, indicating its potential importance in fundamental biological processes.
The protein encoded by C1orf158 contains 427 amino acids and possesses several structural domains, including a coiled-coil domain and a leucine zipper motif. These domains suggest its involvement in protein-protein interactions and cellular signaling pathways.
Associated Diseases
Research has established links between C1orf158 and several diseases, including:
Cancer: C1orf158 has been implicated in the development of various types of cancer, including breast, lung, and esophageal cancer. Studies have demonstrated that C1orf158 expression is altered in cancer cells, potentially contributing to tumor progression and metastasis.
Neurodegenerative Disorders: C1orf158 has been associated with Alzheimer's disease and Parkinson's disease. Genetic variants in C1orf158 have been found to increase the risk of developing these conditions, suggesting its role in neurodegeneration.
Cardiovascular Disease: C1orf158 has been linked to coronary artery disease and heart failure. Individuals with certain genetic variations in C1orf158 have an increased risk of developing these cardiovascular conditions.
Infertility: Mutations in C1orf158 have been identified in women with unexplained infertility. These mutations may impair the proper function of the ovaries and hinder successful fertilization.
Did you Know ?
According to a recent study, individuals carrying a specific genetic variant in C1orf158 have a 25% increased risk of developing Alzheimer's disease compared to those without the variant. This highlights the potential impact of C1orf158 in disease susceptibility.
