C18orf8
c18orf8: A Promising Target in Cancer Research
Description
C18orf8 is a gene that encodes a protein of unknown function. It is located on chromosome 18 and is highly expressed in various tissues, including the brain, lungs, and liver. While its exact role remains elusive, studies have implicated c18orf8 in several important cellular processes, including cell growth, migration, and apoptosis.
Associated Diseases
Mounting evidence suggests that c18orf8 plays a role in the development and progression of several human diseases, particularly cancer. Aberrant expression or mutations in c18orf8 have been linked to:
- Lung cancer: Elevated c18orf8 levels are associated with increased tumor growth, metastasis, and poor prognosis.
- Breast cancer: Overexpression of c18orf8 promotes tumor cell proliferation and invasion.
- Liver cancer: Deregulated c18orf8 expression is linked to hepatocellular carcinoma development and progression.
- Leukemia: C18orf8 has been implicated in the development of acute myeloid leukemia.
- Ovarian cancer: High c18orf8 expression is associated with poor survival in ovarian cancer patients.
Did you Know ?
According to a recent study published in the journal Nature Medicine, c18orf8 overexpression is observed in over 50% of lung cancer tumors. This finding highlights the potential importance of c18orf8 as a diagnostic and therapeutic target in lung cancer.
