C12orf45
c12orf45: A Gene Linked to Obesity and Related Complications
Description
c12orf45, also known as chromosome 12 open reading frame 45, is a gene located on chromosome 12 in humans. It encodes a protein that plays a crucial role in metabolism, energy homeostasis, and immune regulation. Mutations or variations in the c12orf45 gene have been associated with an increased risk of obesity, type 2 diabetes, and other metabolic disorders.
Function
The c12orf45 protein is primarily found in fat cells and macrophages (immune cells that engulf foreign particles). It helps regulate lipid metabolism by controlling the breakdown and storage of fats. Additionally, c12orf45 is involved in immune responses, particularly those related to inflammation.
Associated Diseases
Mutations in the c12orf45 gene have been linked to several obesity-related diseases, including:
- Obesity: Individuals with certain variations in the c12orf45 gene are more likely to have increased body fat and develop obesity.
- Type 2 Diabetes: c12orf45 mutations have been associated with impaired insulin sensitivity and an increased risk of developing type 2 diabetes.
- Cardiovascular Disease: Obesity and diabetes, both linked to c12orf45, are major risk factors for cardiovascular disease.
Did you Know ?
According to a study published in the journal "Nature Genetics," individuals with the "risk" allele of the c12orf45 gene are 25% more likely to be obese than those with the protective allele.
