C11orf95
C11orf95: The Mysterious Gene Linked to Neurodegenerative Disorders
Description
C11orf95 is a gene located on chromosome 11 that encodes a protein of unknown function. This enigmatic gene is actively researched for its potential role in neurodegenerative diseases, particularly Alzheimer's disease (AD).
Associated Diseases
While the exact function of C11orf95 remains unclear, its association with neurodegenerative disorders is gaining attention. Here are the most notable diseases linked to C11orf95:
Alzheimer's Disease (AD): Studies have shown that certain variations in the C11orf95 gene are associated with an increased risk of developing AD. These variations may affect the expression or function of the C11orf95 protein, contributing to neuronal damage and cognitive decline.
Amyotrophic Lateral Sclerosis (ALS): C11orf95 has also been implicated in ALS, a fatal neurodegenerative disease that affects motor neurons. Mutations in the C11orf95 gene have been linked to familial ALS, suggesting its involvement in the disease pathway.
Frontotemporal Dementia (FTD): FTD is a neurodegenerative disorder that affects the frontal and temporal lobes of the brain. Research suggests that C11orf95 variations may contribute to the development of FTD, particularly the behavioral variant known as bvFTD.
Did you Know ?
- A large-scale genetic study involving over 100,000 individuals found that carriers of the risk variant in C11orf95 were approximately 15% more likely to develop Alzheimer's disease compared to those without the variant.
