C10orf11
The Enigmatic c10orf11: A Gene with Diverse Roles and Implications
Description:
c10orf11 is a gene located on chromosome 10 that encodes a protein of unknown function. It spans approximately 20 kilobases and contains 17 exons. The c10orf11 protein is a highly conserved, ubiquitously expressed protein that has been identified in various eukaryotes, including humans, mice, and zebrafish.
Associated Diseases:
While the precise role of c10orf11 remains elusive, research has linked it to a range of diseases, including:
- Cancer: c10orf11 has been implicated in the development of several types of cancer, including breast, lung, and colorectal cancers. Aberrant expression of c10orf11 has been associated with tumor cell proliferation, invasion, and metastasis.
- Neurological Disorders: Mutations in c10orf11 have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These mutations may lead to the accumulation of toxic proteins and neuronal damage.
- Metabolic Disorders: c10orf11 is involved in lipid metabolism. Dysregulation of c10orf11 expression has been associated with disorders such as obesity and type 2 diabetes.
Did you Know ?
Studies have shown that individuals with a specific variant in the c10orf11 gene have an increased risk of developing Alzheimer's disease. This variant is believed to alter the protein's structure and function, potentially affecting its role in neurodegenerative processes.
