BTN3A1
Description
The BTN3A1 (butyrophilin subfamily 3 member A1) is a protein-coding gene located on chromosome 6.
Butyrophilin subfamily 3 member A1 is a protein that in humans is encoded by the BTN3A1 gene. You can find more information about this gene at the UCSC Genome Browser: Human BTN3A1 genome location and BTN3A1 gene details page.
BTN3A1 plays a crucial role in T-cell activation and adaptive immune responses. It regulates the proliferation of activated T-cells, controls the release of cytokines and IFNG by these cells, and mediates their response to infected and transformed cells with high levels of phosphorylated metabolites like isopentenyl pyrophosphate. These functions are supported by several studies (PubMed:21113407, PubMed:21918970, PubMed:22767497, PubMed:22846996).
BTN3A1 is also known as BT3.1, BTF5, BTN3.1, CD277.
Associated Diseases
- type 1 diabetes mellitus
- inflammatory spondylopathy
- schizophrenia
- major depressive disorder
- bipolar disorder
