BTF3
Description
The BTF3 (basic transcription factor 3) is a protein-coding gene located on chromosome 5.
BTF3, encoded by the BTF3 gene in humans, is a key component of basic transcription factor 3. It forms a stable complex with RNA polymerase IIB, which is essential for initiating transcription. BTF3 also interacts with CSNK2B. Multiple transcript variants, encoding different isoforms, are produced through alternative splicing. The gene also has multiple pseudogenes.
BTF3, when paired with NACA, safeguards against non-secretory polypeptides being wrongly directed to the endoplasmic reticulum (ER). It accomplishes this by attaching to newly formed polypeptide chains as they leave the ribosome, blocking their interaction with the signal recognition particle (SRP). The SRP is normally responsible for guiding secretory peptides to the ER. Additionally, BTF3 is a general transcription factor, capable of forming a stable complex with RNA polymerase II, which is essential for initiating transcription.
BTF3 is also known as BETA-NAC, BTF3a, BTF3b, NACB.
Associated Diseases
- Alzheimer disease
- Parkinson disease
- lysosomal storage disease
- multiple sclerosis
- hemoglobin D disease
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- alpha-thalassemia-myelodysplastic syndrome
- dominant beta-thalassemia
- hemoglobin H disease
- hemoglobin C-beta-thalassemia syndrome
- dehydrated hereditary stomatocytosis
- hemoglobin E disease
