BRMS1
Description
The BRMS1 (BRMS1 transcriptional repressor and anoikis regulator) is a protein-coding gene located on chromosome 11.
BRMS1, also known as Breast cancer metastasis suppressor 1, is a protein encoded by the BRMS1 gene in humans. Its primary function is to reduce the metastatic potential of breast cancer and melanoma cell lines without affecting tumorigenicity. BRMS1 resides primarily in the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein exhibits two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing generates two transcript variants, each encoding distinct isoforms.
BRMS1 is also known as -.
Associated Diseases
- endometrial cancer
- breast cancer
- Ehlers-Danlos syndrome, musculocontractural type
- cancer
- pseudohypoaldosteronism type 2B
- pseudohypoaldosteronism type 2D
- isolated hyperchlorhidrosis
- pseudohypoaldosteronism type 2E
- hearing loss-familial salivary gland insensitivity to aldosterone syndrome
