BRF2
Description
The BRF2 (BRF2 RNA polymerase III transcription initiation factor subunit) is a protein-coding gene located on chromosome 8.
BRF2, also known as Transcription factor IIIB 50 kDa subunit (TFIIIB50, hTFIIIB50), is a protein involved in the regulation of gene expression.
BRF2 is a general activator of RNA polymerase III transcription, specifically required for transcription of genes with promoter elements upstream of the initiation sites. BRF2 plays a role in gene expression regulation, acting as an activator under normal conditions and downregulating target genes in response to oxidative stress. Overexpression of BRF2 protects cells from apoptosis during oxidative stress.
BRF2 is also known as BRFU, TFIIIB50.
