BRD7

Description

The BRD7 (bromodomain containing 7) is a protein-coding gene located on chromosome 16.

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene. BRD7 has been shown to interact with IRF2 and HNRPUL1. BRD7 protein is a transcription regulator that is normally highly expressed in the testis, particularly in meiotic pachytene and diplotene spermatocytes and in round spermatids. However, in the testes of patients exhibiting spermatogenesis arrest and azoospermia, BRD7 protein expression is observed to be absent or reduced. Homozygous knockout mice [BRD7(-/-)] are infertile and have increased DNA damage and apoptosis in their germline.

BRD7 acts as both a coactivator and a corepressor, potentially contributing to chromatin remodeling. It activates the Wnt signaling pathway in a DVL1-dependent manner by inhibiting GSK3B's phosphotransferase activity, leading to dephosphorylation of GSK3B at Tyr-216. BRD7 also downregulates TRIM24-mediated transcriptional activation by AR, functioning as a transcriptional corepressor that reduces the expression of target genes. It binds to target promoters, promoting histone H3 acetylation at Lys-9 (H3K9ac). Additionally, BRD7 interacts with the ESR1 promoter and recruits BRCA1 and POU2F1 to this promoter. BRD7 serves as a coactivator for TP53-mediated transcription activation of specific target genes and is crucial for TP53-induced cell cycle arrest in response to oncogene activation. BRD7 enhances TP53 acetylation at Lys-382, facilitating its recruitment to target promoters and inhibiting cell cycle progression from G1 to S phase.

BRD7 is also known as BP75, CELTIX1, NAG4, SMARCI1.

Associated Diseases

WES Whole Exome Sequencing