BPIFB3
BPI Fold-Binding Protein 3 (BPIFB3)
Description:
BPIFB3 is a protein that plays a crucial role in maintaining the epithelial barrier of the gastrointestinal tract. It belongs to the bactericidal/permeability-increasing protein (BPI) family, known for its antimicrobial and immunomodulatory properties. BPIFB3 is secreted by Paneth cells, specialized epithelial cells in the small intestine, and contributes to the innate immune defense against bacterial infection.
Associated Diseases:
Dysregulation of BPIFB3 expression or function has been linked to several gastrointestinal disorders, including:
- Inflammatory bowel disease (IBD): Reduced BPIFB3 levels have been observed in IBD patients, particularly those with Crohn's disease.
- Colorectal cancer: Overexpression of BPIFB3 has been associated with increased cell proliferation and tumor progression in colorectal cancer.
- Pancreatitis: BPIFB3 is implicated in the pathogenesis of pancreatitis, where its levels are elevated and contribute to inflammation and tissue damage.
Did you Know ?
A study published in the journal "Nature Immunology" found that individuals with a specific variant of the BPIFB3 gene have a significantly increased risk of developing Crohn's disease. This variant disrupts the protein's normal function, impairing its ability to combat bacterial infection.
