BNC1
Description
The BNC1 (basonuclin zinc finger protein 1) is a protein-coding gene located on chromosome 15.
BNC1, also known as Zinc finger protein basonuclin-1, is a protein encoded by the BNC1 gene. It is a zinc finger protein found in the basal cell layer of the epidermis and hair follicles, as well as in germ cells of the testes and ovaries. BNC1 is thought to play a regulatory role in keratinocyte proliferation and may also regulate rRNA transcription. The gene has multiple alternatively spliced transcript variants, but their full-length nature is unknown. There are multiple polyadenylation sites for this gene. BNC1 does not interact with PICK1, despite sharing the same abbreviation with the non-voltage gated sodium channel BNC1 (brain Na+ channel 1), which does interact with PICK1. BNC1 and brain Na+ channel 1 are distinct proteins.
Acts as a transcriptional activator and is likely involved in regulating the terminal differentiation of keratinocytes in squamous epithelia and hair follicles (PubMed:8034748). It is essential for maintaining spermatogenesis and plays a role in positively regulating oocyte maturation, likely through control of BMP15 levels and regulation of the AKT signaling cascade (PubMed:30010909). BNC1 may also be involved in the early development of embryos.
BNC1 is also known as BNC, BSN1, HsT19447, POF16, bn1.
