BMX

Description

The BMX (BMX non-receptor tyrosine kinase) is a protein-coding gene located on chromosome X.

BMX, an abbreviation for bicycle motocross or bike motocross, is a cycle sport performed on BMX bikes, either in competitive BMX racing or freestyle BMX, or else in general street or off-road recreation. BMX began during the early 1970s in the United States when children began racing their bicycles on dirt tracks in southern California, inspired by the motocross stars of the time. The size and availability of the Schwinn Sting-Ray and other wheelie bikes made them the natural bike of choice for these races, since they were easily customized for better handling and performance. BMX racing was a phenomenon by the mid-1970s. Children were racing standard road bikes off-road around purpose-built tracks in California. The motorcycle racing documentary On Any Sunday (1971) is generally credited with inspiring the movement nationally in the United States; its opening scene shows kids riding their Sting-Rays off-road. By the middle of that decade, the sport achieved critical mass, and manufacturers began creating bicycles designed especially for the sport. In 1974, George E. Esser founded the National Bicycle League as a non-profit bicycle motocross sanctioning organization. Before they set up the NBL, Esser and his wife, Mary, sanctioned motorcycle races with the American Motocross Association (AMA). Their two sons, Greg and Brian, raced motorcycles, but also enjoyed riding and racing BMX with their friends.

BMX is a non-receptor tyrosine kinase that plays a central role in various signaling pathways involved in regulating cellular processes like actin reorganization, cell migration, proliferation, survival, adhesion, and apoptosis. It participates in signal transduction triggered by a range of receptors including growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors, and integrins. BMX induces tyrosine phosphorylation of BCAR1 in response to integrin regulation, and its activation by integrins is mediated by PTK2/FAK1, a key factor in integrin signaling that regulates the actin cytoskeleton and cell motility. BMX plays a crucial role in TNF-induced angiogenesis, and it's implicated in the signaling of TEK and FLT1 receptors, two important receptor families essential for angiogenesis. BMX is required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation, and it's also involved in interleukin-6 (IL6)-induced differentiation. BMX contributes to programming adaptive cytoprotection against extracellular stress in various cell systems, including salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. It might be involved in regulating endocytosis through its interaction with an endosomal protein RUFY1. BMX may also play a role in the growth and differentiation of hematopoietic cells, as well as in signal transduction in endocardial and arterial endothelial cells.

BMX is also known as ETK, PSCTK2, PSCTK3.

Associated Diseases

WES Whole Exome Sequencing