BMPR2 : bone morphogenetic protein receptor type 2
Description
The BMPR2 (bone morphogenetic protein receptor type 2) is a protein-coding gene located on chromosome 2.
The BMPR2 gene provides instructions for making a protein called bone morphogenetic protein receptor type 2. This protein belongs to a family of genes known for their role in regulating the growth and maturation (differentiation) of bone and cartilage. However, recent research has shown that this gene family has a broader role in regulating the growth and differentiation of various cell types. Bone morphogenetic protein receptor type 2 spans the cell membrane, with one end on the outer surface and the other end remaining inside the cell. This positioning enables the protein to receive and transmit signals that help the cell respond to its environment by growing and dividing (cell proliferation) or undergoing controlled cell death (apoptosis). The balance of cell proliferation and apoptosis regulates the number of cells in tissues.
BMPR2 is also known as BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK.
Associated Diseases
- Pulmonary hypertension, primary, 1
- Pulmonary venoocclusive disease 1
- Pulmonary arterial hypertension
- Pulmonary veno-occlusive disease
