BMP6
Description
The BMP6 (bone morphogenetic protein 6) is a protein-coding gene located on chromosome 6.
Bone morphogenetic protein 6 (BMP6) is a protein encoded by the BMP6 gene in humans. It belongs to the TGFβ superfamily, known for its role in bone and cartilage growth. BMP6 can induce all osteogenic markers in mesenchymal stem cells. BMP6 is involved in early development, potentially due to its expression during embryogenesis. Its close relationship to BMP5 and BMP7 suggests possible bone inductive activity. Recent research (April 2009) has revealed additional functions of BMP6.
BMP6, a member of the TGF-beta superfamily, plays crucial roles in development, including cartilage and bone formation. It regulates HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. BMP6 promotes HAMP expression, potentially through interaction with its receptor BMPR1A/ALK3. BMP6 initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B, leading to phosphorylation of SMAD1/5/8, which then regulate gene expression in the nucleus. BMP6 can also signal through non-canonical pathways like the TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression.
BMP6 is also known as IO, VGR, VGR1.
