BMP10
Description
The BMP10 (bone morphogenetic protein 10) is a protein-coding gene located on chromosome 2.
BMP10 is a human protein encoded by the BMP10 gene. It belongs to the TGF-beta superfamily of proteins and is known for its role in heart development, particularly in the formation of the trabeculae, which are the internal structures of the heart. BMP10 shares a significant sequence similarity with other bone morphogenetic proteins (BMPs), which are known for their ability to induce bone and cartilage development.
BMP10 plays a crucial role in maintaining the proliferation of embryonic heart muscle cells (cardiomyocytes) by preventing premature activation of CDKN1C/p57KIP, a protein that inhibits cell division. It also ensures proper levels of MEF2C and NKX2-5, essential factors for heart development. BMP10 interacts with receptors ACVRL1/ALK1, BMPR1A/ALK3, and BMPR1B/ALK6, triggering the activation of SMAD1, SMAD5, and SMAD8 transcription factors. BMP10 has been shown to inhibit the movement and growth of endothelial cells, which line blood vessels. Additionally, it may reduce cell migration and attachment to the surrounding matrix in breast cancer cells.
BMP10 is also known as -.
