BioExpress Publications


To know more about  BioExpress® System please see

 

https://www.ocimumbio.com/bioexpress-system/

 

2020

 

Overview of cancer genomics, organization, and variations in the human genome

M Yamin, HG Raza, I Fatima - 'Essentials of Cancer Genomic …, 2020 - Springer

… However, microarray data analysis tools like “Gene Logic’s BioExpress ® System Oncology

Suite” and BioExpress ® Oncology Suite are specifically available for cancer research [4]. …

 

 

2019

 

[PDF] 心不全の新規標的分子探索と FITM1 および FITM2 の機能検証

西濱夏海, ニシハマナツミ - 2019 - tsukuba.repo.nii.ac.jp

… ヒト心疾患患者における遺伝子発現変動 第一三共RDノバーレ株式会社に解析を委託し,Bio Express

system(Gene Logic Division, Ocimum Biosolutions)を用いた情報収集を行った.公知情報から,…

 

 

2018

 

 

[PDF] Identification of fat storage-inducing transmembrane proteins 1 and 2 as putative therapeutic targets for heart failure by integrated analysis of proteome and …

N Nishihama, Y Abe, K Kubota… - J Proteom …, 2018 - pdfs.semanticscholar.org

… The expression of all target genes in the heart was assessed by using the BioExpress database (GeneLogic, USA). Total RNA isolation and microarray analysis For the MI model, LV of three sham mice and four MI mice were used …

  Cited by 1 Related articles 

 

Klotho beta

L Desnoyers - US Patent App. 15/701,243, 2018 - Google Patents

… Whisker-box plots showing KLβ ( FIG. 4A ) and FGFR4 ( FIG. 4B ) expression in human tissues, as determined by mRNA analysis of the BioExpress database. The center line indicates the median; the box represents the inter-quartile range between the first and third quartiles …  All 2 versions PDF] googleapis.com

 

 

Compositions and methods for treating and diagnosing cancer

AL Gurney, A Sato - US Patent App. 15/631,259, 2018 - Google Patents

The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cell. The present invention further identifies an interaction between …  All 2 versions 

 

2017

Compositions and methods for treating and diagnosing cancer

AL Gurney, AK Sato - US Patent 9,717,794, 2017 - Google Patents

US9717794B2 - Compositions and methods for treating and diagnosing cancer - Google Patents. Compositions and methods for treating and diagnosing cancer. Download PDF Info. Publication number US9717794B2. US9717794B2 …  Related articles All 4 versions 

 

Compositions and Methods for Treating and Diagnosing Cancer

AL Gurney - US Patent App. 15/441,700, 2017 - Google Patents

The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cells. The present invention further identifies an interaction between …  All 2 versions 

 

 

 

 

 

Rspo binding agents and uses thereof

AL Gurney, FT Axelrod, TC Hoey… - US Patent App. 15 …, 2017 - Google Patents

US20170298143A1 - Rspo binding agents and uses thereof - Google Patents. Rspo binding agents and uses thereof. Download PDF Info. Publication number US20170298143A1. US20170298143A1 US15/480,081 US201715480081A …  All 2 versions 

 

Anti-RSPO2 antibodies and uses thereof

AL Gurney, FT Axelrod, TC Hoey… - US Patent …, 2017 - Google Patents

US9644034B2 - Anti-RSPO2 antibodies and uses thereof - Google Patents. Anti-RSPO2 antibodies and uses thereof. Download PDF Info. Publication number US9644034B2. US9644034B2 US14/795,811 US201514795811A …  Related articles All 2 versions 

 

RSPO3 binding agents and uses thereof

AL Gurney, CJ Bond - US Patent 9,598,497, 2017 - Google Patents

US9598497B2 - RSPO3 binding agents and uses thereof - Google Patents. RSPO3 binding agents and uses thereof. Download PDF Info. Publication number US9598497B2. US9598497B2 US14/870,145 US201514870145A …  Cited by 2 Related articles All 4 versions 

 

RSPO3 Binding Agents and Uses Thereof

AL Gurney, CJ Bond - US Patent App. 15/439,288, 2017 - Google Patents

The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human RSPO3 proteins and modulate β-catenin activity …  All 2 versions 

 

2016

 

Bruton tyrosine kinase–dependent immune cell cross-talk drives pancreas cancer

AJ Gunderson, MM Kaneda, T Tsujikawa, AV Nguyen… - Cancer discovery, 2016 - AACR

 Cited by 181 Related articles All 8 versions

[HTML] sciencedirect.com

 

[HTML] Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study

Y Lin, V Kazlova, S Ramakrishnan, MA Murray, D Fast… - Phytomedicine, 2016 - Elsevier

… using Feature Extraction software, version 9.5.3. Functionally annotated genes (those linked to any metabolic processes) were further analyzed for their relationship to bone health by comparison with the Gene Logic BioExpress ® gene expression database (Markowitz and …  Cited by 11 Related articles All 9 versions

 

Method to improve expression and other biological analysis

R Lehrer - US Patent App. 14/776,621, 2016 - Google Patents

… on a large number of biological samples. For example, Gene Logic's BioExpress system is a database of 22,000 human tissue samples with data generated on the Aggy HU133 2+platform. The data may be selected as those …

  Related articles All 2 versions 

 

Anti-fgfr4 antibodies and methods of use

M Dennis, L Desnoyers, D French - US Patent App. 14/995,111, 2016 - Google Patents

… antibody). FIGS. 6A-6C : FGFR4 expression is deregulated in cancer. A, Whisker-box plots show FGFR4 expression in human tumors and normal tissues as determined by mRNA analysis of the BioExpress database. The center …  Cited by 1 Related articles All 2 versions 

 

Rspo binding agents and uses thereof

AL Gurney, FT Axelrod, TC Hoey… - US Patent App. 14 …, 2016 - Google Patents

US20160002344A1 - Rspo binding agents and uses thereof - Google Patents. 

Rspobinding agents and uses thereof. Download PDF Info. Publication number US20160002344A1. US20160002344A1 US14/795,811 US201514795811A …  All 2 versions 

Safety lead optimization and candidate identification: integrating new technologies into decision-making

DM Dambach, D Misner, M Brock… - Chemical Research …, 2016 - ACS Publications

… Information (NCBI) resources and commercial databases/tools such as BioExpress (Ocimum

Biosolutions), ToxExpress (Ocimum Biosolutions), and ToxWiz (Cambridge Cell Networks). …

 

2014

 

[HTML] Systematic evaluation of connectivity map for disease indications

J ChengL YangV Kumar… - Genome …, 2014 - genomemedicine.biomedcentral

 …… normal) across 124 human tissues were retrieved from the Gene Logic BioExpress™ system [20 … The BioExpress System provides gene expression data and associated clinical and pathological … For each study conducted at Genelogic, the research protocol was approved by one …  Cited by 43 Related articles All 12 versions 

 

IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function

H Matsunaga, K Kubota, T Inoue, F Isono… - … and biophysical research …, 2014 - Elsevier

… Expression data of IQGAP1 gene in normal pancreatic tissues (n = 28) and pancreatic adenocarcinomas (n = 44) were retrieved from BioExpress System (Gene Logic Division, Ocimum Biosolutions, Inc.), gene expression database containing human gene expression profiles …  Cited by 17 Related articles All 7 versions [HTML] sciencedirect.com

 

[HTML] B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas

NI Affara, B Ruffell, TR Medler, AJ Gunderson… - Cancer cell, 2014 - Elsevier

… To address this, we queried cDNA microarray data on a panel of human tumors from the BioExpress System and assessed CD20 (MS4A1) and Ig (IGHG1, IGHG2, IGHV4-31, IGHM) mRNA expression relative to corresponding normal tissue …[PDF] googleapis.com

 

Organ-specific gene, method for identifying the same and use thereof

S Miyamoto, K Takami, A Horinouchi - US Patent App. 13/951,897, 2014 - Google Patents

… Example 1 Materials and Methods; [0111]. 1. Database Used and Method of Data Extraction. [0112]. Gene expression data on male C57BL/6 mice were extracted from BioExpress of GENE LOGIC™ on Apr. 21, 2006. The parameters [HTML] pharmaceuticalintelligence.com

 

[HTML] Archive for January, 2015

NS Abul-Husn, AO Obeng… - …, 2014 - pharmaceuticalintelligence.com

… pairs. The disease signatures were generated using Gene Logic BioExpress system and the compound profiles were derived from the Connectivity Map database (CMAP, build 02, http://www.broadinstitute.org/CMAP/). Results … 

 

Combining bioinformatics and MS-based proteomics: clinical implications

AE Acosta-Martin, L Lane - Expert review of proteomics, 2014 - Taylor & Francis
..Page 1. Combining bioinformatics and MS-based proteomics: clinical implications Expert Rev. Proteomics 11(3), 269–284 (2014) Adelina Elena Acosta-Martin*1,2 and Lydie Lane*1,3 1Department of Human Protein Sciences …

  Cited by 5 Related articles All 7 versions

 

Compositions and methods for treating and diagnosing cancer

A Gurney, AK Sato - US Patent 8,628,774, 2014 - Google Patents

US8628774B2 - Compositions and methods for treating and diagnosing cancer - Google Patents. Compositions and methods for treating and diagnosing cancer. Download PDF Info. Publication number US8628774B2. US8628774B2  Cited by 21 Related articles All 4 versions 

 

Compositions and methods for treating and diagnosing cancer

A Gurney - US Patent 8,883,736, 2014 - Google Patents

..The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies LGR5 as a protein over-expressed in solid tumor stem cells. The present invention further identifies an interaction between …  Cited by 12 Related articles All 4 versions 

 

Anti-RSPO1 antibodies

AL Gurney, FT Axelrod, TC Hoey… - US Patent …, 2014 - Google Patents

..US8802097B2 - Anti-RSPO1 antibodies - Google Patents. Anti-RSPO1 antibodies. Publication number US8802097B2. US8802097B2 US13/549,050US201213549050A US8802097B2 US 8802097 B2 US8802097 …  Cited by 11 Related articles All 2 versions 

 

[PDF] Effect of novel glass-lonomer cements on human osteoblasts

J Sangsuwan - 2014 - kb.psu.ac.th

..Page 1. Effect of Novel Glass- Ionomer Cements on Human Osteoblasts Jiraporn Sangsuwan A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science in Molecular Biology and Bioinformatics Prince of Songkla University 2014 …

 

 

 

2013

 

[HTML] Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis

D Lötsch, E Steiner, K Holzmann, S Spiegl-Kreinecker… - Oncotarget, 2013 - ncbi.nlm.nih.gov

… A. MVP mRNA expression data in normal (green) and malignant (red) brain tissues as well as tumour cell cultures (yellow), determined by gene expression array analyses,were extracted from the BioExpress database (GeneLogic) …  Cited by 44 Related articles All 12 versions

 

 

 

Ocimum Biosolutions: Genomics Outsourcing in India

A Knauer - Women Entrepreneurs, 2013 - content.taylorfrancis.com

… Ocimum's database, purchased in the Gene Logic acquisition, is con - sidered the largest and most comprehensive in the industry. There are a number of public databases available that lack the ease of use and reliability of information of BioExpress …[PDF] googleapis.com

 

Organ-specific gene, method for identifying the same and use thereof

S Miyamoto, K Takami, A Horinouchi - US Patent 8,535,880, 2013 - Google Patents

… Gene expression data on male C57BL/6 mice were extracted from BioExpress of GENE LOGIC™ on Apr. 21, 2006 … [Results]. 1. Data Used. The data used were extracted from the gene expression database BioExpress, introduced from GENE LOGIC™ …  Related articles All 4 versions [PDF] googleapis.com

 

Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them

G Adolf, E Ostermann, M Kalat, KH Heider - US Patent 8,568,727, 2013 - Google Patents

..Anti-FAP-antibodies and immunoconjugates, pharmaceutical compositions containing such conjugates, and their use in cancer therapy.  Cited by 16 Related articles All 4 versions [HTML] nih.gov

 

Gene expression in the human brain: the current state of the study of specificity and spatiotemporal dynamics

OY Naumova, M Lee, SY Rychkov… - Child …, 2013 - Wiley Online Library Skip to Main Content …  Cited by 32 Related articles All 9 versions

 

Compositions and methods for treating and diagnosing cancer

A Gurney - US Patent 8,540,989, 2013 - Google Patents

US8540989B2 - Compositions and methods for treating and diagnosing cancer - Google Patents. Compositions and methods for treating and diagnosing cancer. Download PDF Info. Publication number US8540989B2. US8540989B2 … Cited by 22 Related articles All 4 versions 

 

RSPO Binding Agents and Uses Thereof

AL Gurney, FT Axelrod, TC Hoey… - US Patent App. 13 …, 2013 - Google Patents

US20130095116A1 - RSPO Binding Agents and Uses Thereof - Google Patents. RSPO Binding Agents and Uses Thereof. Download PDF Info. Publication number US20130095116A1. US20130095116A1 US13/549,050 US201213549050A …  Cited by 18 Related articles All 2 versions 

 

 

2012

 

Applications of Connectivity Map in drug discovery and development

XA Qu, DK Rajpal - Drug discovery today, 2012 - Elsevier

…of marketed drugs and compounds. BioExpress™, http://www.genelogic.com/knowledge-suites/bioexpress-system, Commercial database for human disease-centric gene expression data. Library of Integrated Network-based …  Cited by 139 Related articles All 4 versions [HTML] plos.org

 

[HTML] Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models

DM French, BC Lin, M Wang, C Adams, T Shek… - PloS one, 2012 - journals.plos.org

 ..The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes. It is also well documented that dysregulation of FGF-FGFR signaling may have important roles in tumor development and …  Cited by 132 Related articles All 14 versions [PDF] aacrjournals.org  Free from Publisher

 

Expression of g protein-coupled receptor 19 in human lung cancer cells is triggered by entry into s-phase and supports g2–m cell-cycle progression

S Kastner, T Voss, S Keuerleber, C Glöckel… - Molecular Cancer …, 2012 - AACR  Cited by 18 Related articles All 9 versions

 

Bioinformatics advances for clinical biomarker development

KPH Pritzker, LB Pritzker - Expert opinion on medical diagnostics, 2012 - Taylor & Francis

… features BioExpress System GeneLogic http://www.genelogic.com Whole genomeGene expression database with histopathology, clinical chemistry, hematology, treatment, follow-up and other clinical details Thomson Reuters …  Cited by 6 Related articles All 3 versions [PDF] googleapis.com

 

Tetrahydrofolate synthetase gene

T Sugiura - US Patent 8,168,392, 2012 - Google Patents

… The gene whose expression is elevated in the cancer cell in comparison with the normal cell was identified making use of the microarray data base of Bioexpress (Genelogic). Expression profile data in respective cells of 117 …  Related articles All 4 versions  [PDF] googleapis.com

 

Method for treatment of pancreatitis

LA TartagliaTM Barnes, RM Coopersmith… - US Patent App. 13 …, 2012 - Google Patents

US20120009183A1 - Method for treatment of pancreatitis - Google Patents. Method for treatment of pancreatitis. Download PDF Info. Publication number US20120009183A1. US20120009183A1 US13/171,058 US201113171058A …  All 2 versions

 

 

Treatment of breast cancer with iodonitrobenzamides in combination with anti-tumor agents

BM Sherman, C Bradley… - US Patent App. 13/430,475, 2012 - Google Patents

US20120269861A1 - Treatment of breast cancer with iodonitrobenzamides in combination with anti-tumor agents - Google Patents. Treatment of breast cancer with iodonitrobenzamides in combination with anti-tumor agents. Download PDF Info …  All 2 versions  

 

[PDF] Investigation into the role of novel interferon lambdas in the treatment of viral disease, primarily hepatitis C

RM Lowe - 2012 - core.ac.uk… 124 5.3 Gene Logic human tissue microarray screen ..... 127 … Figure 5.2 A: Gene Logic graph showing IFNAR1 expression in a range of human cell types and tissues ..... 128 …  Related articles All 3 versions [PDF] unsw.edu.au

 

[PDF] CHARACTERISING THE ROLE OF TRIM16 IN DIFFERENTIATION, PROLIFERATION AND TUMOUR DEVELOPMENT IN NEUROBLASTOMA

JL Bell - unsworks.unsw.edu.au

Page 1. CHARACTERISING THE ROLE OF TRIM16 IN DIFFERENTIATION, PROLIFERATION AND TUMOUR DEVELOPMENT IN NEUROBLASTOMA By Jessica Lilian Bell This thesis is submitted in fulfilment of the requirements for the degree …

 

Compositions and methods for treating and diagnosing cancer

A Gurney - US Patent 8,158,758, 2012 - Google Patents

US8158758B2 - Compositions and methods for treating and diagnosing cancer - Google Patents. Compositions and methods for treating and diagnosing cancer. Download PDF Info. Publication number US8158758B2. US8158758B2 …

 

Compositions and methods for treating and diagnosing cancer

AL Gurney, AK Sato - US Patent 8,158,757, 2012 - Google Patents

US8158757B2 - Compositions and methods for treating and diagnosing cancer - Google Patents. Compositions and methods for treating and diagnosing cancer. Download PDF Info. Publication number US8158757B2. US8158757B2 

 

 

2011

 

Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation

Y Hiruma, T Hirai, E Tsuda - Biochemical and biophysical research …, 2011 - Elsevier

… To identify GCT-related genes, we relied on the BioExpress System developed by Gene

Logic, containing Affymetrix U133 oligonucleotide microarray expression profiles of numerous …

 

Knowledge-Driven, Data-Assisted Integrative Pathway Analytics

PS Reddy, S Murray, W Liu - Handbook of Research on …, 2011 - books.google.com

... mechanisms. Examples include ICONIX's Drug Matrix (Ganter, Snyder, Halbert, & Lee, 2006) and Gene Logic's BioExpress (http://www. genelogic. com/knowledge-suites/bioexpress-system)(Katz, 231 Page 266. Knowledge... 

Related articles All 3 versions Cite [HTML] from europepmc.org

 

 

 

2010

 

[HTML] Molecular biomarker analyses using circulating tumor cells

EA Punnoose, SK Atwal, JM Spoerke, H Savage… - PloS one, 2010 - journals.plos.org

… 32], [33]. To examine the expression of marker genes in primary tumors, gene expression profiles were extracted from the commercially available database BioExpress (GeneLogic, Gaithersburg MD). Cell surface expression …

  Cited by 297 Related articles All 17 versions  [PDF] sagepub.com  Full View

 

Upregulation of poly (ADP-ribose) polymerase-1 (PARP1) in triple-negative breast cancer and other primary human tumor types

V Ossovskaya, IC Koo, EP Kaldjian… - Genes & …, 2010 - journals.sagepub.com

Poly (ADP-ribose) polymerase-1 (PARP1) is a key facilitator of DNA repair and is implicated in pathways of tumorigenesis. PARP inhibitors have gained recent att...  Cited by 160 Related articles All 5 versions [PDF] wiley.com Full View

 

TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro‐hepatocyte growth factor

T Hashimoto, M Kato, T Shimomura… - The FEBS …, 2010 - Wiley Online Library

… members of the TTSP family. These proteases have been shown to be co‐expressed with HAI‐1 in various tissues (database of BioExpress System, Gene Logic Inc.,Gaithersburg, MD, USA). Then, the putative activation cleavage …  Cited by 63 Related articles All 8 versions

 

EGFL6 is increasingly expressed in human obesity and promotes proliferation of adipose tissue-derived stromal vascular cells

R Oberauer, W Rist, MC Lenter, BS Hamilton… - Molecular and cellular …, 2010 - Springer

… Affymetrix GeneChip analysis in a wide range of human normal tissues (BioExpress ® database,Gene Logic) showed high expression of EGFL6 in placenta, lung, and fat, whereas most other tissues displayed weak or no expression indicating that EGFL6 expression is rather …  Cited by 31 Related articles All 10 versions

 

Information technology solutions for integration of biomolecular and clinical data in the identification of new cancer biomarkers and targets for therapy

H Hackl, G Stocker, P Charoentong, B Mlecnik… - Pharmacology & …, 2010 - Elsevier

Skip to main content Skip to article …  Cited by 10 Related articles All 6 versions [PDF] amegroups.com

 

 

Mutated genes in pancreatic cancer

S He, D Li - Chinese Journal of Cancer Research, 2010 - Springer

… Cao D et al utilized the Gene Logic Inc. BioExpress™ platform and Affymetrix U133 GeneChip® set to determine the changes in gene expression associated with SMAD4 gene inactivation in a series of well-characterized pancreatic cancer cell lines to define the downstream …  Cited by 2 Related articles All 7 versions 

 

Diagnoses and therapeutics for cancer

DR Wonsey, MT Follettie - US Patent 7,655,402, 2010 - Google Patents

US7655402B2 - Diagnoses and therapeutics for cancer - Google Patents. Diagnoses and therapeutics for cancer. Download PDF Info. Publication number US7655402B2. US7655402B2 US11051679 US5167905A US7655402B2 …

  Cited by 17 Related articles All 4 versions 

 

Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents

BM Sherman, C Bradley - US Patent 7,732,491, 2010 - Google Patents

In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer …  Cited by 36 Related articles All 4 versions 

 

Method for treating inflammatory diseases of the digestive tract

LA TartagliaTM Barnes, RM Coopersmith… - US Patent …, 2010 - Google Patents

US7842709B2 - Method for treating inflammatory diseases of the digestive tract - GooglePatents. Method for treating inflammatory diseases of the digestive tract. Download PDF Info. Publication number US7842709B2. US7842709B2 …  Cited by 16 Related articles All 4 versions 

 

Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents

BM Sherman, C Bradley - US Patent App. 12/496,593, 2010 - Google Patents

US20100003192A1 - Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents - Google Patents. Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents. Download PDF Info …  Cited by 6 Related articles All 2 versions 

 

Method for reducing gastrointestinal adverse effects of cytotoxic agents

SR Donahue, JJ Byrnes - US Patent App. 12/704,286, 2010 - Google Patents

A method for moderating a gastrointestinal adverse effect induced by at least one cytotoxic agent, for example ionizing radiation and/or at least one chemotherapeutic agent, in a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor …  All 2 versions 

 

Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in conbination with anti-tumor agents

BM Sherman, C Bradley - US Patent App. 12/502,943, 2010 - Google Patents

US20100009930A1 - Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in conbination with anti-tumor agents - Google Patents. Treatment of uterine cancer and ovarian cancer with a parp inhibitor …

  Cited by 6 Related article

 

Methods for breast cancer screening and treatment

D White, S Jin, RM Coopersmith… - US Patent App. 12 …, 2010 - Google Patents

US20100029734A1 - Methods for breast cancer screening and treatment - Google Patents. Methods for breast cancer screening and treatment. Download PDF Info. Publication number US20100029734A1. US20100029734A1 …

  Cited by 6 Related articles All 2 versions 

 

Method For Identification of Compound Having Anti-Anxiety Effect

D Okajima, H Yokota, O Ohara, T Nagase… - US Patent App. 12 …, 2010 - Google Patents

There are provided a method for identifying a compound having an anti-anxiety effect, an inhibitor of a function of a protein having a function as a G-protein coupled receptor, characterized by finding the protein and a gene encoding the protein and using at least one of a DNA represented …

  Related articles All 2 versions 

 

 

 

2009

Functional characterisation of calcium-activated chloride channel 2 (CLCA2) in human tumour cells

DS Kozina - 2009 - othes.univie.ac.at

Page 1. DISSERTATION Titel der Dissertation Functional Characterisation of Calcium-Activated Chloride Channel 2 (CLCA2) in Human Tumour Cells angestrebter akademischer Grad Doktorinder Naturwissenschaften (Dr. rer.nat.) Verfasserin / Verfasser: Mag. Daniela Kozina …

  Related articles All 2 versions 

 

 

Similar compounds searching system by using the gene expression microarray database

H Toyoshiba, H Sawada, I Naeshiro, A Horinouchi - Toxicology letters, 2009 - Elsevier

… Tong et al., 2003), ArrayExpress at the EBI (Parkinson et al., 2007), the Toxicogenomics Project (TGP) (Takashima et al., 2006), Iconix DrugMatrix, the GeneLogic ToxExpress and BioExpress, and the NCBI microarray data repository Gene Expression Omnibus (GEO) (www.ncbi …  Cited by 16 Related articles All 5 versions

 

Tetrahydrofolate synthetase gene

T Sugiura - US Patent 7,534,562, 2009 - Google Patents

US7534562B2 - Tetrahydrofolate synthetase gene - Google Patents. Tetrahydrofolate synthetase gene. Download PDF Info. Publication number US7534562B2. US7534562B2 US10/573,969 US57396904A US7534562B2 US …

  Cited by 1 Related articles All 4 versions 

 

 

Method for treatment of pancreatitis

LA TartagliaTM Barnes, RM Coopersmith… - US Patent App. 12 …, 2009 - Google Patents

A method for treating acute or chronic pancreatitis in a subject comprises administering to the subject a therapeutically effective amount of an ACE2 inhibitor...  Related articles All 2 versions 

 

Inhibition of urokinase-type plasminogen activator (uPA) activity

JF Bazan, P Kirk - US Patent App. 12/290,013, 2009 - Google Patents

The invention concerns methods for inhibiting the binding of urokinase-type plasminogen activator (uPA) to its receptor uPAR and/or inhibiting uPA biological activity. The invention further concerns methods for inhibiting tumor formation or metastasis, angiogenesis, such as tumor …  All 2 versions 

 

 

Molecular cardiotoxicology modeling

DL Mendrick, KR Johnson - US Patent App. 12/064,933, 2009 - Google Patents

… WO 02/095659, published Nov. 23, 2002, and US Pat. No. 5,953,727, which are herein incorporated by reference in their entirety. In a preferred embodiment, the database is a ToxExpress® or BioExpress database marketed by Gene Logic Inc., Gaithersburg, Md …  Related articles All 2 versions 

 

Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents

BM Sherman, C Bradley… - US Patent App. 12/269,833, 2009 - Google Patents

US20090123419A1 - Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents - Google Patents. Treatment of uterine cancer and ovarian cancer with a parp inhibitor …

  Cited by 23 Related articles All 2 versions 

 

Method for treating er+ breast cancer

RM Coopersmith, DW White, S Jin… - US Patent App. 12 …, 2009 - Google Patents

US20090012052A1 - Method for treating er+ breast cancer - Google Patents. Method for treating er+ breast cancer. Download PDF Info. Publication number US20090012052A1. US20090012052A1 US12/100,053 US10005308A …

  Cited by 7 Related articles All 2 versions 

 

Assay employing a g-protein coupled receptor that is activated by CCK-8S

O Ohara, T Nagase, M Ohishi, D Okajima… - US Patent …, 2009 - Google Patents

US7527937B2 - Assay employing a g-protein coupled receptor that is activated byCCK-8S - Google Patents. Assay employing a g-protein coupled receptor that is activated by CCK-8S. Download PDF Info. Publication number …

  Cited by 2 Related articles All 2 versions 

 

 

 

2008

 

 

[HTML] Molecular analysis of the vaginal response to estrogens in the ovariectomized rat and postmenopausal woman

SA Jelinsky, SE Choe… - BMC medical …, 2008 - bmcmedgenomics.biomedcentral …

… First, all qualifiers were annotated with unigene accession numbers through BioExpress (GeneLogic) … In order to do this, probe set annotations and ortholog assignments were obtainedfrom BioExpress 2.0 (GeneLogic) and NCBI Homologene, respectively …  Cited by 9 Related articles All 12 versions 

 

Protein phosphatase 1H, overexpressed in colon adenocarcinoma, is associated with CSE1L

T Sugiura, Y Noguchi, K Sakurai… - Cancer biology & …, 2008 - Taylor & Francis

… Data mining of the BioExpress database. We identified the genes upregulated in human colon adenocarcinomas using the BioExpress database (Gene Logic Inc., Gaithersburg, MA, USA) comprising the Affymetrix U133 GeneChip expression profiles as described previously …  Cited by 24 Related articles All 3 versions

 

Preventive and/or Therapeutic Agent for Cancer

T Yoshikawa, W Watanabe… - US Patent App. 11/547,334, 2008 - Google Patents

… For example, 69 kinds of genes highly expressed in pancreatic cancer were tried to be identifiedusing BioExpress (Gene Logic Co., Ltd.) in … of SEQ ID NOS: 1 to 4 were selected by the followingprocedures using an expression profile database, BioExpress (GeneLogic Co., Ltd …  Related articles All 2 versions 

 

 

Characterization of TRIM31, upregulated in gastric adenocarcinoma, as a novel RBCC protein

T Sugiura, K Miyamoto - Journal of cellular biochemistry, 2008 - Wiley Online Library

… MATERIALS AND METHODS. Data Mining of the BioExpress Database. We identified the genes upregulated in human stomach adenocarcinoma by using the BioExpress database (Gene Logic Inc., Gaithersburg, MA) as described previously [Sugiura et al., 2004, 2007b] …

 

A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95

T Sugiura, A Yamaguchi, K Miyamoto - Experimental cell research, 2008 - Elsevier

… Materials and methods. Identification of RNF43 upregulated in colon cancers. Expression profiles of RNF43 in various normal and diseased tissues were analyzed by virtue of the BioExpress database (Gene Logic Inc., Gaithersburg, MA) as described previously [10], [11] …  Cited by 49 Related articles All 9 versions

 

[HTML] Differential expression of multiple genes in association with MADH4/DPC4/SMAD4 inactivation in pancreatic cancer

D Cao, R Ashfaq, MG GogginsRH Hruban… - … journal of clinical and …, 2008 - ncbi.nlm.nih.gov

… in other tumor types [4, 5]. Considering the high rate of MADH4 inactivation in pancreatic cancers, it is attractive to consider the genes differentially expressed in accord with MADH4 status in anunbiased survey [6–9]. We utilized the Gene Logic Inc. BioExpress(tm) platform and …  Cited by 15 Related articles All 8 versions

 

Evolution of closely linked gene pairs in vertebrate genomes

E Franck, T HulsenMA Huynen… - Molecular biology …, 2008 - academic.oup.com

… Gene Expression. An expression data set consisting of a subset of normal human and mouse tissue samples from the Gene Logic BioExpress Database product (http://www.genelogic.com/genomics/bioexpress/) was used. The …

  Cited by 15 Related articles All 13 versions

 

 

From pharmacogenomics to translational biomarkers

DL Mendrick - Essential Concepts in Toxicogenomics, 2008 - Springer

… renal cell carcinoma was recently described (21). Examination of Kim-1 in human renal diseases was performed using the BioExpress® database at Gene Logic (Gaithersburg,MD). The expression of Kim-1 mRNA was significantly 

  Cited by 1 Related articles All 5 versions

 

[HTML] Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

N Yamasaki, M Maekawa… - Molecular …, 2008 - molecularbrain.biomedcentral.com

Elucidating the neural and genetic factors underlying psychiatric illness is hampered by current methods of clinical diagnosis. The identification and investigation of clinical endophenotypes may be one solution, but represents a considerable challenge in human subjects. Here we …  Cited by 206 Related articles All 19 versions 

 

Methods For Molecular Toxicology Modeling

JC Diggans, M Elashoff - US Patent App. 10/580,423, 2008 - Google Patents

… WO 02/095659, published Nov. 23, 2002, and US Pat. No. 5,953,727, which are herein incorporated by reference in their entirety. In a preferred embodiment, the database is a ToxExpress® or BioExpress® database marketed by Gene Logic Inc., Gaithersburg, Md …  Related articles All 2 versions 

 

Method for reducing or alleviating inflammation in the digestive tract

LA TartagliaTM Barnes, RM Coopersmith… - US Patent App. 11 …, 2008 - Google Patents

US20080234345A1 - Method for reducing or alleviating inflammation in the digestive tract - Google Patents. Method for reducing or alleviating inflammation in the digestive tract. Download PDF Info. Publication number US20080234345A1 …  Cited by 1 Related articles All 2 versions

 

 

Toxicogenomic predictive modeling: emerging opportunities for more efficient drug discovery and development

A Amir-Aslani - Technological Forecasting and Social Change, 2008 - Elsevier

Skip to main content …  Cited by 12 Related articles All 3 versions

 

 

Breast cancer screening and treatment methods

RM Coopersmith, DW White, S Jin… - US Patent App. 11 …, 2008 - Google Patents

US20080132474A1 - Breast cancer screening and treatment methods - Google Patents. Breast cancer screening and treatment methods. Download PDF Info.Publication number US20080132474A1. US20080132474A1 US11 …

  Cited by 2 Related articles All 2 versions 

 

hGPR87 contributes to viability of human tumor cells

S Glatt, D Halbauer, S Heindl… - … journal of cancer, 2008 - Wiley Online Library

… One hundred divided by the trimmed mean gives the scaling factor, where 100 is the standard value used by GeneLogic … The human sample collection has been described by the originator of the BioExpress database.17 Numbers in brackets indicate the sample numbers …Cited by 45 Related articles All 6 versions

 

Gene Encoding a Guanine Nucleotide Exchange Factor Binding to Rhoa

O Ohara, T Nagase, M Ohishi, H Yokota… - US Patent App. 11 …, 2008 - Google Patents

A gene encoding a novel protein that binds to a Rho family protein being one group of small GTP binding proteins and is capable of exhibiting a GEF activity, namely, a polynucleotide shown by the nucleotide sequence set forth in SEQ ID NO: 1, or SEQ ID NO: 3, or the complementary …

  Cited by 1 Related articles All 2 versions 

 

Gene Encoding a Guanine Nucleotide Exchange Factor and Its Gene Product

O Ohara, T Nagase, M Ohishi, H Yokota… - US Patent App. 11 …, 2008 - Google Patents

US20080274954A1 - Gene Encoding a Guanine Nucleotide Exchange Factor and Its Gene Product - Google Patents. Gene Encoding a Guanine Nucleotide Exchange Factor and Its Gene Product. Download PDF Info. Publication …

 

2007

 

[PDF] DDX39, upregulated in lung squamous cell cancer, displays RNA helicase activities and promotes cancer cell growth

T Sugiura, Y Nagano, Y Noguchi - Cancer biology & therapy, 2007 - Taylor & Francis

… For this purpose we resorted to the gene expression profile database called BioExpress developed by GeneLogic Inc., which utilizes the Affimetrix … Initially we collected 130 normal lung, 74 LAC and 51 LSCC patient samples on the BioExpress (Gene Logic Inc.) database …Cited by 48 Related articles All 3 versions

 

Molecular characterization of the desmoplastic tumor stroma in medullary thyroid carcinoma

O Koperek, C Scheuba, C Puri… - International …, 2007 - spandidos-publications.com

… in normal and tumor tissues. The expression levels of FAPα, Tn-C and α-SMA in thyroid cancers were analyzed by querying the Gene Logic Bioexpress database (see Materials and methods). In this database, we obtained the …Cited by 54 Related articles All 7 versions

 

Liver-specific activities of FGF19 require Klotho beta

BC Lin, M Wang, C Blackmore… - Journal of Biological …, 2007 - ASBMB

… KLB and FGFR4 Distribution Dictate FGF19 Tissue-specific Activity—We evaluated KLB and FGFR4 expression in a variety of human tissues by analyzing the BioExpress data base (Gene Logic, Inc.). In decreasing order of …Cited by 218 Related articles All 6 versions

 

Bioinformatics approaches in the study of cancer

DA HanauerDR Rhodes… - Current molecular …, 2007 - ingentaconnect.com

… The BioExpress® Oncology Suite offers visualization and statistical analysis tools as well … Similar to Gene Logic's offerings is the Oncomine [13] database Fig … [19] http://www.genelogic.com/ docs/pdfs/OncologyProductSheet.pdf Accessed on April 22, 2006 …Cited by 69 Related articles All 12 versions

 

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL

KW Wagner, EA Punnoose, T Januario, DA Lawrence… - Nature medicine, 2007 - nature.com

Article. Cited by 555 Related articles All 11 versions

 

The Connectivity Map: a new tool for biomedical research

J Lamb - Nature reviews cancer, 2007 - nature.com

… Iconix's DrugMatrix contains data for the effects of systemic administration of hundreds of drugs on many rat tissues 44, and Gene Logic's BioExpress has thousands of profiles from normal, diseased and drug-treated human and animal tissues and cell lines …Cited by 655 Related articles All 7 versions

 

PARP1 gene over-expression in primary human cancers: A potential marker for PARP inhibition

V Ossovskaya, C Alvares, E Kaldjian, B Sherman - 2007 - AACR

Skip to main content. AACR Journals: Cancer Discovery; Cancer Epidemiology, Biomarkers & Prevention; Cancer Immunology Research; Cancer Prevention Research; Cancer Research; Clinical Cancer Research; Molecular Cancer Research; Molecular Cancer Therapeutics ..cited by 3 Related articles

 

From the bench to the clinic and back again: translational biomarker discovery using in silico mining of pharmacogenomic data

DL Mendrick, KK Daniels - 2007 - Future Medicine

… In silico mining of pharmacogenomic data within Gene Logic's BioExpress ® and ToxExpress ® databases quickly reveals that the expression of Kim-1 in normal human tissues resides primarily in the kidney (Figure 1). A low level of expression was found in normal mouse …Cited by 8 Related articles All 6 versions

 

 

[CITATION] P57 The PARP1 gene is over-expressed in triple negative breast cancer

V Ossovskaya, C Alvares, E Kaldjian… - EJC …, 2007 - annalsjournal.com

… PARP1. Methods: We used the Gene Logic BioExpress® System database to analyze PARP1 expression in human ovarian, breast, uterine, lung and prostate tumor samples in comparison to normal counterpart tissues. Gene …Cited by 1 Related articles All 3 versions

 

[CITATION] P50 Expression of estrogens, progesterone and c-erbB-2 in patients with recurrent breast cancer in Mexico

JM Ornelas-Aguirre, LM Perez-Michel… - EJC …, 2007 - annalsjournal.com

… PARP1. Methods: We used the Gene Logic BioExpress® System database to analyze PARP1 expression in human ovarian, breast, uterine, lung and prostate tumor samples in comparison to normal counterpart tissues. Gene …

 

[CITATION] P10 Identification of possible metastasis associated markers expressed on the surface of a breast cancer model

N Rasmussen, HJ Ditzel - EJC Supplements, 2007 - annalsjournal.com

… PARP1. Methods: We used the Gene Logic BioExpress® System database to analyze PARP1 expression in human ovarian, breast, uterine, lung and prostate tumor samples in comparison to normal counterpart tissues. Gene …All 7 versions

 

[CITATION] P27 Antiangiogenic activity of combining gefitinib and rapamycin in a panel of pancreas cancer cell lines

L Pocelli, A Azzariti, GM Simone, G Gatti… - EJC …, 2007 - annalsjournal.com

… PARP1. Methods: We used the Gene Logic BioExpress® System database to analyze PARP1 expression in human ovarian, breast, uterine, lung and prostate tumor samples in comparison to normal counterpart tissues. Gene …All 3 versions

 

[HTML] A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart

O Seguchi, S Takashima, S Yamazaki… - The Journal of …, 2007 - Am Soc Clin Investig

… peptide (BNP) mRNA levels (194 probe sets). The tissue localization of each selected probe set was then analyzed using the commercially available BioExpress database (Gene Logic Inc.). We selected 10 probe sets, for which …Cited by 126 Related articles All 14 versions

 

Patterns of gene expression in the limbic system of suicides with and without major depression

A Sequeira, T Klempan, L Canetti, C Benkelfat… - Molecular …, 2007 - nature.com

… (Gaithersburg, MD, USA, www.genelogic.com). All microarray data and clinical information were embedded into Gene Logic's Genesis 2.0 software as a component of its Bioexpress system. RNA samples used in the current study had a minimum A260/A280 ratio of 1.9 …Cited by 148 Related articles All 18 versions

 

[BOOK] Pharmacophylogenomics: Explaining interspecies differences in drug discovery

T Hulsen - 2007 - repository.ubn.ru.nl

Page 1. PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/30197 …  Related articles All 5 versions 

 

Compositions and methods for diagnosing and treating cancers

X Be, W Liu, D Slonim, S Howes - US Patent App. 11/509,413, 2007 - Google Patents

… Genes (CRTPGs). Gene expression data in eight malignant tumor sample sets (ie, breast, colon, esophagus, kidney, liver, lung, prostate, and stomach cancer sample sets) was compared to the corresponding normal counterparts in the Gene Logic BioExpress™ database …  Cited by 2 Related articles All 2 versions 

 

Identification of adiponutrin-related proteins as esterases and methods of use for the same

R Gimeno, J Paulsen, JL Li, A Lake, W Liu… - US Patent App. 11 …, 2007 - Google Patents

US20070014776A1 - Identification of adiponutrin-related proteins as esterases and methods of use for the same - Google Patents. Identification of adiponutrin-related proteins as esterases and methods of use for the same. Download PDF Info …  Cited by 10 Related articles All 2 versions 

 

Methods and apparatuses for diagnosing AML and MDS

M Burczynski, A Dorner, N Twine… - US Patent App. 11 …, 2007 - Google Patents

Methods, systems and equipment for diagnosing or monitoring the progression or treatment of AML or MDS. This invention identifies a plurality of AML or MDS disease genes which are differentially expressed in bone marrow cells of AML or MDS patients as compared to disease …

 

 

 

 

2006

 

Expression of stromal cell markers in distinct compartments of human skin cancers

MA Huber, N Kraut, N Schweifer… - Journal of cutaneous …, 2006 - Wiley Online Library

… tumor‐relevant genes. The expression levels of FAP, endoglyx‐1, and endosialin in human skin cancers were analyzed by querying the GeneLogic Bioexpress ®database (see Materials and methods). In this database, we …

Cited by 64 Related articles All 7 versions

 

[HTML] Benchmarking ortholog identification methods using functional genomics data

T HulsenMA Huynen, J de Vlieg… - Genome …, 2006 - genomebiology.biomedcentral.com

The transfer of functional annotations from model organism proteins to human proteins is one of the main applications of comparative genomics. Various methods are used to analyze cross-species orthologous relationships according to an operational definition of orthology. Often …  Cited by 179 Related articles All 18 versions 

 

[HTML] A summarization approach for Affymetrix GeneChip data using a reference training set from a large, biologically diverse database

S Katz, RA Irizarry, X Lin… - BMC …, 2006 - bmcbioinformatics.biomedcentral …

… We have utilized an alternate RMA workflow that includes two distinct steps: (a) training of an RMA model based on a large number of biologically distinct Affymetrix GeneChip samples from Gene Logic's BioExpress reference database and (b) application of the resulting RMA …

 

 

TTLL7 is a mammalian β-tubulin polyglutamylase required for growth of MAP2-positive neurites

K Ikegami, M Mukai, J Tsuchida, RL Heier… - Journal of Biological …, 2006 - ASBMB

… Using BioExpress Data Base—We performed a data base search and statistical analysis on TTLL mRNA expression among various tissues in humans that were profiled by Affymetrix GeneChip technology and stored in the commercial Gene Logic BioExpress data base system …  Cited by 131 Related articles All 9 versions

 

Detecting and profiling tissue-selective genes

S Liang, Y Li, X Be, S Howes, W Liu - Physiological genomics, 2006 - physiology.org

Login to your account. Institutional Login. Sign In / Register. PHYSIOLOGY.ORG Skip main navigationClose Drawer MenuOpen Drawer Menu Home: Journals: AJP-Cell; AJP-Endo; AJP-GI; AJP-Heart; AJP-Lung; AJP-Regu; AJP-Renal; …  Cited by 64 Related articles All 8 versions

Translational medicine: the discovery of bridging biomarkers using pharmacogenomics

DL Mendrick - 2006 - Future Medicine

… At Gene Logic we have large reference gene expression databases with accompanying clinical annotation of normal and diseased human tissue (BioExpress ® database) and vehicle and toxicant treated tissues and cells from multiple species (ToxExpress ® database) …Cited by 7 Related articles All 4 versions

 

Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes

T Hatanaka, Y Hatanaka, J Tsuchida… - Journal of Biological …, 2006 - ASBMB

… We performed a data base search and statistical analysis on ATA2 mRNA and GLUT4 mRNA expression among various tissues in humans, mice, and rats that were profiled by Affymetrix GeneChip technology and stored in the commercial Gene Logic BioExpress data base …  Cited by 44 Related articles All 7 versions

 

Toxicogenomics and cross-species biomarker discovery: applications in drug discovery and safety assessment

MS Orr - Toxicology mechanisms and methods, 2006 - Taylor & Francis

… for leveraging toxicogenomic information from rats contained in one database (ToxExpress @R database) and genomic information from human samples contained in a second database (BioExpress @ R database) in … At Gene Logic Inc., Affymetrix GeneChips @ R microarrays …Cited by 8 Related articles All 7 versions

 

Inhibiting HER2 shedding with matrix metalloprotease antagonists

K Carey, R Schwall, M Sliwkowski… - US Patent App. 11 …, 2006 - Google Patents

US20060177448A1 - Inhibiting HER2 shedding with matrix metalloprotease antagonists -Google Patents. Inhibiting HER2 shedding with matrix metalloprotease antagonists. Download PDF Info. Publication number US20060177448A1 …  Cited by 10 Related articles All 2 versions 

 

[BOOK] Application of Toxicogenomics to Cross-Species Extrapolation: A Report of a Workshop

National Research Council - 2006 - books.google.com

… For exam- ple, the fibrosis genes differentially dysregulated between dog and rat liver included INHBE (activin beta E). To determine whether these canine genes might be relevant to hu- man fibrosis, Gene Logic's BioExpress database of normal and diseased human tissue …

 

Mig6 is a negative regulator of EGF receptor–mediated skin morphogenesis and tumor formation

I Ferby, M Reschke, O Kudlacek, P Knyazev, G Pantè… - Nature medicine, 2006 - nature.com

… We analyzed ERRFI1 expression levels in 3,200 normal and cancer samples using the BioExpress database, which contains transcriptional profiles obtained from … 100 divided by the trimmed mean gives the scaling factor, where 100 is the standard value used by GeneLogic …Cited by 213 Related articles All 12 versions

 

Gene encoding G-protein coupled receptor and gene product thereof

O Ohara, T Nagase, M Ohishi, D Okajima… - US Patent App. 11 …, 2006 - Google Patents

The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein …

Cited by 3 Related articles All 2 versions 

 

 

 

2005

 

 

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients

RL Yauch, T Januario, DA Eberhard, G Cavet… - Clinical Cancer …, 2005 - AACR

Skip to main content. AACR Publications: Cancer Discovery; Cancer Epidemiology, Biomarkers & Prevention; Cancer Immunology Research; Cancer Prevention Research; Cancer Research; Clinical Cancer Research; Molecular Cancer Research; Molecular Cancer Therapeutics … Cited by 580 Related articles All 8 versions

 

Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin

H Dolznig, N Schweifer, C Puri, N Kraut, WJ Rettig… - Cancer Immunity …, 2005 - AACR

Cited by 139 Related articles All 4 version 

 

 

Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe

DR Wonsey, MT Follettie - Cancer research, 2005 - AACR

Skip to main content. AACR Publications: Cancer Discovery; Cancer Epidemiology, Biomarkers & Prevention; Cancer Immunology Research; Cancer Prevention Research; Cancer Research; Clinical Cancer Research; Molecular Cancer Research; Molecular Cancer Therapeutics …Cited by 323 Related articles All 5 versions

 

Revealing Transforming Growth Factor–β Signaling Transduction in Human Kidney by Gene Expression Data Mining

G Hu, K Jain, M Hurle - Omics: a journal of integrative biology, 2005 - liebertpub.com

… From the BioExpress® System, Gene Logic Inc.'s (Gaithersburg, MD http://www.genelogic.com/)database of human U133 GeneChip® microarray data processed using MAS5.0, we chose 227 datasets derived from kid- ney samples that met three conditions: (i) scale factors …Cited by 6 Related articles All 3 versions

 

[HTML] Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

AR Abbas, D Baldwin, Y Ma, W Ouyang, A Gurney… - Genes and …, 2005 - nature.com

Cited by 290 Related articles All 13 versions

 

Clusters of adjacent and similarly expressed genes across normal human tissues complicate comparative transcriptomic discovery

C Liu, S Ghosh, DB Searls, AM Saunders… - Omics: a journal of …, 2005 - liebertpub.com

… retrieved gene expression data profiled using human U133A&B chips (Affymetrix, Santa Clara, CA; www.affymetrix.com) for 2695 normal human samples belonging to 101 tissue types from BioExpress Sys- tem Database (Gene Logic Inc., Gaithersburg, MD; www.genelogic.com …  Cited by 6 Related articles All 3 versions

 

 

The delicate toxicity balance in drug discovery: can pricey late-stage failures--or dangerous drugs--be prevented with better products for predicting drug toxicity?

U Sankar - The Scientist, 2005 - go.galegroup.com

… Sertanty QSAR software and Knowledge-based drug services discovery Tripos Discovery informatics Preclinical development and chemical compound libraries Iconix DrugMatrix, Pharmotif Predictive toxicology Gene Logic ToxExpress, BioExpress Predictive toxicology In Vitro …Cited by 35 Related articles All 2 versions

 

Cell surface molecules as markers and therapeutic agents against kidney cancers

W Liu, M WhitleyD Slonim, S Howes - US Patent App. 10/671,740, 2005 - Google Patents

… [0052]. The data mining power of microarrays is encompassed in another research tool, namely BioExpress™, a comprehensive database of biological information from Gene Logic Inc. (Gaithersburg, Md.), which we used for …

  Cited by 5 Related articles All 2 versions 

 

[BOOK] Analyzing microarray gene expression data

G McLachlanKA DoC Ambroise - 2005 - books.google.com

Page 1. Analyzing Mieroarray Gene Expression Data Page 2. This Page Intentionally Left Blank Page 3. Analyzing Microarray Gene Expression Data Page 4. WILEYERIES IN PROBABILITY AND STATISTICS Established by …Cited by 685 Related articles All 8 versions

 

Compositions and methods for diagnosing and treating cancers

X Be, W Liu, D Slonim, S Howes - US Patent App. 10/847,918, 2005 - Google Patents

US20050119210A1 - Compositions and methods for diagnosing and treating cancers -Google Patents. Compositions and methods for diagnosing and treating cancers.Download PDF Info. Publication number US20050119210A1 …

 

 

Compositions and methods for diagnosing, preventing, and treating cancers

E Brown, W Liu - US Patent App. 10/770,726, 2005 - Google Patents

US20050266409A1 - Compositions and methods for diagnosing, preventing, and treating cancers - Google Patents. Compositions and methods for diagnosing, preventing, and treating cancers. Download PDF Info. Publication …

  Cited by 17 Related articles All 2 versions 

 

Methods and apparatuses for diagnosing AML and MDS

M Burczynski, A Dorner, N Twine… - US Patent App. 10 …, 2005 - Google Patents

US20050202451A1 - Methods and apparatuses for diagnosing AML and MDS - Google Patents. Methods and apparatuses for diagnosing AML and MDS. Download PDF Info. Publication number US20050202451A1. US20050202451A1 …Cited by 10 Related articles All 2 versions 

 

 

 

2004

 

A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma

T Sugiura, Y Nagano, T Inoue, K Hirotani - Biochemical and biophysical …, 2004 - Elsevier

… We collected 117 normal and 77 adenocarcinoma colon samples on the BioExpress database (Gene Logic Inc., Gaithersburg, MA) containing Affymetrix U133 GeneChip expression profiles [3], [4]. The Fold Change analysis tool equipped in the database was utilized to identify …Cited by 33 Related articles All 6 versions

 

Identification and validation of novel androgen-regulated genes in prostate cancer

AM Velasco, KA Gillis, Y Li, EL Brown, TM Sadler… - …, 2004 - academic.oup.com

Abstract. Androgen-regulated genes (ARGs) are essential for the development of the prostate. Ironically, ARGs are also responsible for the pathogenesis of pros.Cited by 128 Related articles All 8 versions

[PDF] tandfonline.com

Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags

D Cao, SR Hustinx, G Sui, P Bala, N Sato… - Cancer biology & …, 2004 - Taylor & Francis

… completion of the human genome sequence provides a basis for characterizing these ESTs in greater detail using computational and experimental methods.7 In this study we utilized the GeneLogic Inc. BioExpress™ platform and the most current version of Affymetrix GeneChip …Cited by 60 Related articles All 5 versions

 

Endothelial lipase and HDL metabolism

M Jaye, J Krawiec - Current opinion in lipidology, 2004 - journals.lww.com

Purpose of review In the past year, several laboratories taking independent approaches have provide..Cited by 61 Related articles All 8 versions

 

Serial analysis of gene expression (SAGE): application in cancer research

R TutejaN Tuteja - Medical Science Monitor, 2004 - medscimonit.com

… lack of effective treatments. In a recent study the Gene Logic Inc. BioExpress platform and Affymetrix GeneChip arrays were used to identify genes differentially expressed in pan- creatic cancer [12]. The cDNA was hybridized …

Cited by 26 Related articles All 7 versions

 

[PDF] Assessing the quality of clusters in microarray data–a comparison of functional and numerical measures

EVA BERGLUND - 2004 - ibg.uu.se

… This value is referred to as RNA QC. 2.4 The dataset The dataset used in this project originates from BioExpress, a non-public database from Gene Logic (Gene Logic Inc, Gaithersburg, MD, USA). The database stores post-mortem 

 

 

 

2003

 

Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma

NC Twine, JA Stover, B Marshall, G Dukart, M Hidalgo… - Cancer research, 2003 - AACR

Skip to main content. AACR Publications: Cancer Discovery; Cancer Epidemiology, Biomarkers & Prevention; Cancer Immunology Research; Cancer Prevention Research; Cancer Research; Clinical Cancer Research; Molecular Cancer Research; Molecular Cancer Therapeutics …Cited by 142 Related articles All 9 versions

 

[PDF] Determining the Tissue Distribution and Specificity of JM27/G antigen, family C, 1, a Prostate Cancer-associated Gene

P Kulkarni, G Logic - ocimumbio.com

… e-Northern™ and BioExpress™ Human Atlas Suite are trademarks of Gene Logic Inc. PHONE: 301-987-1700 •FAX: 301-987-1701 • www.genelogic.com • Corporate Headquarters: 708 Quince Orchard Road•Gaithersburg, Maryland 20878 BioExpress™ is a registered …

 

Expression profiling identifies a novel α-methylacyl-CoA racemase exon with fumarate hydratase homology

GL Shen-Ong, Y Feng, DA Troyer - Cancer research, 2003 - AACR

Skip to main content. AACR Publications: Cancer Discovery; Cancer Epidemiology, Biomarkers & Prevention; Cancer Immunology Research; Cancer Prevention Research; Cancer Research; Clinical Cancer Research; Molecular Cancer Research; Molecular Cancer Therapeutics …

Cited by 37 Related articles All 6 versions

 

[BOOK] Comparing NR Expression among Metabolic Syndrome Risk Factors

A Jacobsson - 2003 - diva-portal.org

… 42 5.2.1 Lifestyle analysis with the GeneLogic GUI.....43 … humans. BioExpress™ (Gene Logic Inc.) is a database that contains both clinical data and gene expression data from donors in the United States … Cited by 1 Related articles 

 

Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three …

CA Iacobuzio-Donahue, R Ashfaq, A MaitraNV Adsay… - Cancer research, 2003 - AACRCited by 456 Related articles All 12 versions

 

[HTML] Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

Y Miyamoto, A MaitraB Ghosh, U Zechner, P Argani… - Cancer cell, 2003 - Elsevier

Skip to main content …Cited by 701 Related articles All 11 versions

 

[BOOK] Using nuclear receptor interactions as biomarkers for metabolic syndrome

K Hettne - 2003 - diva-portal.org

… Gene Logic is a company that provides functional genomics information products, ser- vices and bioinformatics tools, which focus on human biology and pathology (GeneLogic 2003) … BioExpress TM database, the ToxExpress TM collection of predictive models, and Gen …  Related articles 

 

15 The Future of Toxicogenomics

JC Rockett - An Introduction to Toxicogenomics, 2003 - books.google.com

Page 316. 15 The Future of Toxicogenomics John C. Rockett CONTENTS 15.1 Introduction..... 299 15.2 Technology … Cited by 2 Related articles

 

 

 

2002

 

 

 Discovery of novel tumor markers of pancreatic cancer using global gene expression technology

CA Iacobuzio-DonahueA Maitra, GL Shen-Ong… - The American journal of …, 2002 - Elsevier

… to identify additional potential markers of pancreatic carcinoma, we used the Gene Logic Inc …BioExpress platform and Affymetrix GeneChip arrays to identify genes differentially expressed in a … This mismatch control is analyzed using the GeneLogic informatics filter that compares …Cited by 335 Related articles All 11 versions

 

Expression profiling of a human cell line model of prostatic cancer reveals a direct involvement of interferon signaling in prostate tumor progression

J Shou, R Soriano, SW Hayward… - Proceedings of the …, 2002 - National Acad Sciences

… Furthermore, in silico data-mining with the GeneLogic database revealed that expression of the IFN-inducible genes was down-regulated in approximately 30% of the 49 clinicallycharacterized samples of prostatic adenocarcinomas …Cited by 96 Related articles All 11 versions

 

[BOOK] Predicting gene expression using artificial neural networks

L Lindefelt - 2002 - diva-portal.org

… 2.7 Data The gene expression data used for this project is from a database that AstraZeneca has leased from the company Gene Logic Inc. The database consists of the three sub- databases BioExpress, ToxExpress and PharmExpress. BioExpress consists of gene …

 

 

 

2001

 

Applying data warehouse concepts to gene expression data management

VM Markowitz, T Topaloglou - Proceedings 2nd Annual IEEE …, 2001 - ieeexplore.ieee.org

… Gene Logic's GeneExpress® database products contain gene expression data generated using primarily the … GeneExpress products are available as DataSuites, such as BioExpress and ToxExpress … disease or tissue specific samples (see http://www.genelogic.com/gexpress …

 

 

 

2000

 

 

Differentiating genomics companies

R James - Nature biotechnology, 2000 - nature.com

… Another database, BioExpress, contains gene expression measurements from a wide range of human tissue samples in normal, diseased, and treated conditions, as well as extensive clinical information on all of the tissue donors. Like Incyte, Gene Logic has a number of big …Cited by 16 Related articles All 7 versions

 

High-throughput gene expression analysis for drug discovery

GG Lennon - Drug Discovery Today, 2000 - Elsevier

… Gene Logic currently incorporates the Affymetrix GeneChip probe array in its closed gene expression studies, while using the open READS system for detecting novel genes … One GeneExpress database (BioExpress ™ ) is used primarily for target selection and prioritization …

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