BIRC8
Description
The BIRC8 (baculoviral IAP repeat containing 8) is a pseudo gene located on chromosome 19.
BIRC8 (Baculoviral IAP Repeat-containing protein 8), also known as cellular inhibitor of apoptosis protein 2 (cIAP2), is a human gene that encodes a protein involved in apoptosis regulation. It acts as a potent inhibitor of apoptosis by binding and ubiquitinating various proteins involved in caspase activation, including caspase-3, caspase-7, and caspase-9. These interactions result in the degradation of these caspases, effectively preventing the activation of the caspase cascade and subsequent apoptotic cell death. BIRC8 also plays a role in NF-κB signaling pathway activation, a pathway crucial for inflammatory responses and immune regulation.
BIRC8, also known as cIAP2, is a member of the inhibitor of apoptosis (IAP) family of proteins. It plays a crucial role in regulating apoptosis, a programmed cell death process, by inhibiting caspase activation. BIRC8 interacts with and ubiquitinates various proteins, including caspase-3, caspase-7, and caspase-9, leading to their degradation and preventing apoptosis. Additionally, BIRC8 participates in NF-κB signaling pathway activation, a crucial pathway involved in inflammatory responses and immune regulation. Its involvement in apoptosis and NF-κB signaling makes BIRC8 a key regulator of cell survival, inflammation, and immune responses.
BIRC8 is also known as ILP-2, ILP2, RNF136, hILP2.
