BIRC2
Description
The BIRC2 (baculoviral IAP repeat containing 2) is a protein-coding gene located on chromosome 11.
Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene. cIAP1 is a member of the Inhibitor of Apoptosis family that inhibit apoptosis by interfering with the activation of caspases. BIRC2 has been shown to interact with:
BIRC2, also known as cIAP1, is a multifunctional protein that plays a crucial role in regulating various cellular processes, including apoptosis, inflammation, immunity, cell proliferation, and invasion. It acts as an E3 ubiquitin-protein ligase, modulating NF-κB signaling by positively regulating the canonical pathway while suppressing constitutive activation of the non-canonical pathway. This activity is directed toward various target proteins, including RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE, and MXD1/MAD1. BIRC2 also functions as an E3 ubiquitin-protein ligase in the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Further, it plays a significant role in innate immune signaling by regulating pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLRs), and RIG-I-like receptors (RLRs). BIRC2 protects cells from spontaneous ripoptosome formation, a multi-protein complex involved in cancer cell death, by ubiquitinating RIPK1 and CASP8. Additionally, BIRC2 can stimulate E2F1 transcriptional activity and participate in cell cycle regulation.
BIRC2 is also known as API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1.
