BECN2
Description
The BECN2 (beclin 2) is a protein-coding gene located on chromosome 1.
BECN2 is involved in two distinct lysosomal degradation pathways: autophagy, where it acts as a regulator, and the turnover of G-protein coupled receptors (GPCRs). Specifically, BECN2 regulates the degradation of GPCRs in lysosomes through its interaction with GPRASP1/GASP1.
BECN2 is also known as BECN1L1, BECN1P1.
Associated Diseases
- obesity due to melanocortin 4 receptor deficiency
- type 2 diabetes mellitus
- hypoinsulinemic hypoglycemia and body hemihypertrophy
- transient neonatal diabetes mellitus
- severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency
- short stature due to primary acid-labile subunit deficiency
- diabetes mellitus, permanent neonatal 4
- diabetes mellitus, transient neonatal, 2
- permanent neonatal diabetes mellitus 1
- obesity due to SIM1 deficiency
- obesity due to leptin receptor gene deficiency
- hyperinsulinemic hypoglycemia, familial, 1
- hyperinsulinism due to HNF1A deficiency
- hyperinsulinemic hypoglycemia, familial, 2
- type 1 diabetes mellitus
- pancreatic beta cell agenesis with neonatal diabetes mellitus
- hyperinsulinism due to INSR deficiency
