BCRP3
Description
The BCRP3 (BCR pseudogene 3) is a pseudo gene located on chromosome 22.
BCRP3 is a transmembrane protein that acts as an ATP-binding cassette (ABC) transporter, responsible for the efflux of a wide range of substrates, including drugs, toxins, and steroid hormones, from cells. It plays a role in drug resistance in cancer cells, particularly in breast cancer, and also contributes to the regulation of cell growth, differentiation, and detoxification processes.
BCRP3 (Breast Cancer Resistance Protein 3), also known as ABCG2, is a transmembrane protein that acts as an ATP-binding cassette (ABC) transporter. It plays a crucial role in the efflux of a wide range of substrates, including drugs, toxins, and steroid hormones, from cells. This efflux activity contributes to the development of resistance to various chemotherapeutic agents in cancer cells, particularly in breast cancer. Additionally, BCRP3 is involved in the regulation of cell growth, differentiation, and detoxification processes. Its expression is highly variable across different tissues and cell types, suggesting its diverse roles in maintaining cellular homeostasis.
BCRP3 is also known as BCR3, BCRL3, BCRL6.
