BCRP2
Description
The BCRP2 (BCR pseudogene 2) is a pseudo gene located on chromosome 22.
BCRP2 is a gene that encodes a transmembrane protein called Breast Cancer Resistance Protein 2 (BCRP2) or ABCG2. This protein functions as an efflux transporter, actively removing a variety of substrates, including drugs, toxins, and bile acids, from cells. BCRP2 is particularly important in protecting cells from harmful substances, contributing to drug resistance in certain cancers, and regulating the absorption and disposition of drugs in the gut and liver.
BCRP2, also known as ABCG2, is a transmembrane protein that acts as an efflux transporter, primarily localized to the apical membrane of epithelial cells. It plays a crucial role in the detoxification of various endogenous and exogenous compounds, including toxins, drugs, and bile acids. BCRP2's activity contributes to drug resistance in cancer cells by removing chemotherapeutic agents from the cell, and it also regulates the absorption and disposition of various drugs in the gut and liver.
BCRP2 is also known as BCR-2, BCR2, BCRL2.
