BCL9
Description
The BCL9 (BCL9 transcription coactivator) is a protein-coding gene located on chromosome 1.
BCL9, encoded by the BCL9 gene, is a protein that functions as a transcriptional cofactor for beta-catenin, along with its paralogue BCL9L. These proteins are crucial for the transcription of Wnt target genes, particularly in cardiac development. While BCL9 is primarily associated with Wnt signaling, it also participates in other tissue-specific molecular mechanisms. Its conserved homology domain HD1 interacts with TBX3 in the context of intestinal carcinogenesis. Clinically, BCL9 is linked to B-cell acute lymphoblastic leukemia and may be involved in translocations within B-cell malignancies. The overexpression of BCL9 is potentially pathogenic in B-cell malignancies. Both BCL9 and BCL9L are potential targets for human cancer treatment due to their association with poor outcomes in colorectal cancer.
BCL9 is also known as LGS.
