BCL2L10
Description
The BCL2L10 (BCL2 like 10) is a protein-coding gene located on chromosome 15.
BCL2L10 (Bcl-2-like protein 10) is a human gene that encodes a protein belonging to the BCL-2 protein family. These proteins form dimers and act as regulators of apoptosis, either promoting or inhibiting cell death. BCL2L10 contains conserved BH4, BH1, and BH2 domains and interacts with other members of the BCL-2 family, including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of BCL2L10 suppresses cell apoptosis, possibly by preventing the release of cytochrome C from mitochondria, which in turn prevents caspase-3 activation. The mouse counterpart of BCL2L10 interacts with Apaf1 and forms a complex with Caspase 9, suggesting its involvement in the APAF1 and CASP9 apoptotic pathway.
BCL2L10 promotes cell survival by inhibiting apoptosis triggered by BAX, but not BAK. It enhances the binding of AHCYL1/IRBIT to ITPR1, thereby reducing calcium release from the endoplasmic reticulum under normal conditions. However, during apoptotic stress, BCL2L10 detaches from ITPR1 and relocates from mitochondria-associated endoplasmic reticulum membranes, leading to increased calcium transfer to mitochondria and promoting apoptosis. BCL2L10 is crucial for proper formation of the microtubule organizing center during oocyte cell division, potentially by regulating the abundance and localization of other microtubule organizing center components like AURKA and TPX2.
BCL2L10 is also known as BCL-B, Boo, Diva, bcl2-L-10.
