BCL2A1
Description
The BCL2A1 (BCL2 related protein A1) is a protein-coding gene located on chromosome 15.
BCL2A1 gene encodes a protein belonging to the bcl2 family, which plays a crucial role in regulating cell death. These proteins form dimers and act as either anti- or pro-apoptotic regulators, involved in a range of cellular processes like embryonic development, homeostasis, and tumorigenesis. The BCL2A1 protein can prevent the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct target of NF-kappa B, responding to inflammatory mediators and is activated by various signals such as GM-CSF, CD40, phorbol ester, TNF, and IL-1. This suggests a protective function for the protein, essential for lymphocyte activation and cell survival. In melanocytic cells, BCL2A1 gene expression is potentially controlled by MITF. BCL2A1 protein interacts with Bcl-2-associated X protein and Bcl-2-associated death promoter.
BCL2A1 delays apoptosis caused by IL-3 deprivation. It might play a role in hemopoietic cells' response to external signals and help maintain endothelial survival during infections. Additionally, BCL2A1 can block apoptosis induced by serum starvation in the mammary epithelial cell line HC11.
BCL2A1 is also known as ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1.
