BCCIP
Description
The BCCIP (BRCA2 and CDKN1A interacting protein) is a protein-coding gene located on chromosome 10.
BCCIP, short for BRCA2 and CDKN1A-interacting protein, is a protein encoded by the BCCIP gene in humans. This protein was identified due to its interactions with BRCA2 and p21 proteins. It is a highly conserved nuclear protein with multiple interaction domains. Its N-terminal half exhibits similarities to regions of calmodulin and M-calpain, suggesting it may also bind calcium. Research suggests that BCCIP may be a crucial cofactor for BRCA2 in tumor suppression and a modulator of CDK2 kinase activity through p21. Several transcript variants encoding different isoforms have been identified for this gene. BCCIP has been shown to interact with BRCA2, P21, and PTPmu (PTPRM).
BCCIP plays a critical role in microtubule organization and anchoring during interphase, and in spindle pole organization and stabilization during mitosis. Isoform 2/alpha is particularly important for regulating microtubule anchoring, stability, spindle architecture, and orientation compared to isoform 1/beta. BCCIP may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. It may also be required for the repair of DNA damage by homologous recombination in conjunction with BRCA2. However, it may not be involved in non-homologous end joining (NHEJ).
BCCIP is also known as TOK-1, TOK1.
