BCAR1

Description

The BCAR1 (BCAR1 scaffold protein, Cas family member) is a protein-coding gene located on chromosome 16.

BCAR1 is a protein encoded by the BCAR1 gene. It is located on chromosome 16, region q, on the negative strand, and consists of seven exons. Eight different gene isoforms have been identified, all sharing the same sequence starting from the second exon onwards but differing in their starting sites. The longest isoform, BCAR1-iso1, is 916 amino acids long. BCAR1 is ubiquitously expressed and acts as an adaptor molecule, originally identified as the major substrate of v-Src and v-Crk. It belongs to the Cas family of adaptor proteins and can act as a docking protein for several signaling partners. BCAR1 regulates a variety of signaling pathways involved in cell adhesion, migration, invasion, apoptosis, hypoxia, and mechanical forces. It plays a role in cell transformation and cancer progression, and alterations in its expression and the resulting activation of selective signaling pathways are associated with the development of different types of human tumors. BCAR1 is regulated by phosphorylation and dephosphorylation, and its expression and phosphorylation can have various functional consequences. Receptor tyrosine kinases (RTKs) and integrins play a prominent role in regulating its tyrosine phosphorylation.

BCAR1 is a docking protein that plays a central role in coordinating tyrosine kinase-based signaling related to cell adhesion. It is also involved in cell migration, cell branching, and BCAR3-mediated inhibition of TGFβ signaling.

BCAR1 is also known as CAS, CAS1, CASS1, CRKAS, P130Cas.

Associated Diseases

WES Whole Exome Sequencing