BAIAP3
Description
The BAIAP3 (BAI1 associated protein 3) is a protein-coding gene located on chromosome 16.
BAIAP3 is a protein encoded by the BAIAP3 gene in humans. It was identified as a protein-binding partner of BAI1, a p53-target gene that encodes a brain-specific angiogenesis inhibitor. BAIAP3 is a seven-span transmembrane protein belonging to the secretin receptor family and interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. It contains two C2 domains, often found in proteins involved in signal transduction or membrane trafficking. The expression pattern and similarities to other proteins suggest a potential role in synaptic functions.
BAIAP3 is involved in the retrograde transport of vesicles from endosomes to the Golgi apparatus. It interacts with SNARE proteins and membrane phospholipids in response to calcium influx, facilitating the fusion of endosomes with the trans-Golgi network. This promotes the recycling of transmembrane proteins in secretory vesicles, indirectly impacting the biogenesis, maturation, and secretion of neurotransmitters and hormones. BAIAP3 may also regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters such as NPY and serotonin, as well as hormones like insulin. Additionally, it is suggested to play a role in hypothalamic neuronal firing by modulating GABAergic inhibitory neurotransmission.
BAIAP3 is also known as BAP3.
