BAG2
Description
The BAG2 (BAG cochaperone 2) is a protein-coding gene located on chromosome 6.
BAG2, or BAG family molecular chaperone regulator 2, is a protein encoded by the BAG2 gene in humans. BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. They share a common BAG domain near their C terminus, but their N-terminal regions differ. BAG2 contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 specifically interact with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins bind to the ATPase domain of Hsc70 with high affinity and inhibit its chaperone activity in a Hip-repressible manner. BAG2 interacts with HSPA8.
BAG2 acts as a co-chaperone for HSP70 and HSC70 chaperone proteins. It functions as a nucleotide-exchange factor (NEF), promoting the release of ADP from HSP70 and HSC70, which triggers the release of bound client/substrate proteins.
BAG2 is also known as BAG-2, dJ417I1.2.
Associated Diseases
- Carpenter syndrome
- RAB23-related Carpenter syndrome
- cancer
- coronary atherosclerosis
- hypoparathyroidism, familial isolated, 2
- diabetes mellitus, permanent neonatal 4
- diabetes mellitus, transient neonatal, 3
- permanent neonatal diabetes mellitus 1
- pseudohypoparathyroidism type 2
- glycogen storage disorder due to hepatic glycogen synthase deficiency
