BACE1-AS
Description
The BACE1-AS (BACE1 antisense RNA) is a ncRNA gene located on chromosome 11.
BACE1-AS, also known as BACE1 antisense RNA, is a human gene located at 11q23.3 that encodes a long noncoding RNA molecule. It is transcribed from the opposite strand of the BACE1 gene and is upregulated in patients with Alzheimer's disease. BACE1-AS regulates BACE1 expression by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. This leads to increased levels of beta-amyloid, the main component of senile plaques. BACE1-AS concentrations are elevated in individuals with Alzheimer's disease and in amyloid precursor protein transgenic mice. Knocking down BACE1-AS reduces amyloid production and plaque deposition.
BACE1-AS is also known as BACE1-AS1, BACE1AS, NCRNA00177.
