AZIN2

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Description

The AZIN2 (antizyme inhibitor 2) is a protein-coding gene located on chromosome 1.

Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is a protein encoded by the AZI2 gene in humans. While initially suggested, AzI2 does not function as arginine decarboxylase (ADC) in mammalian cells.

Antizyme inhibitor 2 (AZI2) is a protein that plays a crucial role in regulating polyamine levels by positively influencing ornithine decarboxylase (ODC) activity and polyamine uptake. AZI2, an enzymatically inactive homolog of ODC, counteracts the inhibitory effects of ODC antizymes (OAZ1, OAZ2, and OAZ3) by competing for antizyme binding. This competition prevents ODC degradation and facilitates the formation of the active ODC homodimer, ultimately restoring polyamine production. Additionally, AZI2 contributes to the structural integrity of the trans-Golgi network (TGN) and acts as a regulator of intracellular secretory vesicle trafficking.

AZIN2 is also known as ADC, AZI2, AZIB1, ODC-p, ODC1L, ODCp.

Associated Diseases

• hyperinsulinism due to INSR deficiency
• hyperinsulinism due to glucokinase deficiency
• exercise-induced hyperinsulinism
• hyperinsulinemic hypoglycemia, familial, 4
• hyperinsulinemic hypoglycemia, familial, 1
• islet cell adenomatosis
• hyperinsulinemic hypoglycemia, familial, 2
• hyperinsulinism-hyperammonemia syndrome
• cancer
• spinal cord injury
• bacterial urinary tract infection
• mastocytoma