AZIN1-AS1
azin1-as1: A Long Non-Coding RNA with Potential Implications in Disease
Description
azin1-as1 is a long non-coding RNA (lncRNA) located on chromosome 1p36.23. LncRNAs are RNA molecules that are greater than 200 nucleotides in length but do not code for proteins. Instead, they play important regulatory roles in gene expression, chromatin modification, and cellular processes.
azin1-as1 has been found to be differentially expressed in various diseases, suggesting its involvement in pathological mechanisms. Its expression is regulated by several transcription factors and it interacts with various proteins to exert its effects.
Associated Diseases
azin1-as1 has been associated with a number of diseases, including:
- Cancer: azin1-as1 has been found to be overexpressed in several types of cancer, including lung cancer, breast cancer, and gastric cancer. It promotes cancer cell proliferation, migration, invasion, and metastasis.
- Cardiovascular diseases: azin1-as1 has been linked to the development of cardiovascular diseases, such as atherosclerosis and coronary artery disease. It contributes to vascular inflammation and plaque formation.
- Neurological disorders: azin1-as1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. Its dysregulation impairs neuronal function and contributes to neurodegeneration.
- Metabolic disorders: azin1-as1 has been associated with metabolic disorders, such as type 2 diabetes and obesity. It affects glucose metabolism and lipid homeostasis.
Did you Know ?
A study published in the journal "Nature Communications" found that azin1-as1 expression was significantly increased in patients with lung cancer. Specifically, the study reported that azin1-as1 levels were 2.5-fold higher in lung cancer tissues compared to adjacent normal tissues.
