AZGP1
Description
The AZGP1 (alpha-2-glycoprotein 1, zinc-binding) is a protein-coding gene located on chromosome 7.
AZGP1, also known as zinc-alpha-2-glycoprotein (ZAG), is a glycoprotein found in human plasma. It was discovered in 1961 and is encoded by the AZGP1 gene located on chromosome 7q22.1. AZGP1 is expressed in various tissues and fluids, including breast, stomach, liver, prostate, plasma, urine, and saliva. This protein stimulates lipolysis, leading to fat reduction in mice, and is associated with cancer-related cachexia. Smoking increases its expression, explaining weight gain after quitting. Decreased AZGP1 levels are linked to diabetes 2. AZGP1 serves as a biomarker in cancer patients, with low expression indicating unfavorable outcomes in various cancers, including gastric, esophageal squamous cell, liver, bladder, and prostate cancers.
AZGP1 is also known as ZA2G, ZAG.
