ATRAID
Description
The ATRAID (all-trans retinoic acid induced differentiation factor) is a protein-coding gene located on chromosome 2.
ATRAID (Apoptosis-related protein 3) is a human gene that is thought to be involved in apoptosis. It may also play a role in hematopoietic development and differentiation. Two different isoforms of the protein are encoded by the gene due to alternative splicing.
ATRAID promotes osteoblast cell differentiation and terminal mineralization. It plays a role in cell cycle arrest by inhibiting CCND1 expression in the all-trans-retinoic acid (ATRA) signaling pathway. Within osteoclasts, ATRAID forms a transporter complex with nitrogen-containing-bisphophonates (N-BPs), enabling the release of these molecules into the cytosol after they have been trafficked to lysosomes through fluid-phase endocytosis.
ATRAID is also known as APR--3, APR-3, APR3, C2orf28, HSPC013, PRO240, p18.
Associated Diseases
- early-onset non-syndromic cataract
- hereditary hyperferritinemia with congenital cataracts
- cancer
- isolated ectopia lentis
- cataract 13 with adult I phenotype
- cataract 38
