ATP9A
Description
The ATP9A (ATPase phospholipid transporting 9A (putative)) is a protein-coding gene located on chromosome 20.
Probable phospholipid-transporting ATPase IIA is a protein that in humans is encoded by the ATP9A gene.
ATP9A plays a crucial role in regulating membrane trafficking of cargo proteins, particularly in the recycling of endosome to plasma membrane, likely through the activation of RAB5 and RAB11. Additionally, it is involved in the retrograde transport of material from the endosome to the trans-Golgi network. In complex with MON2 and DOP1B, ATP9A regulates the endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues, through the SNX3 retromer pathway. This complex facilitates the formation of endosomal carriers that direct WLS back to the Golgi, preventing its degradation in lysosomes. ATP9A seems to be involved in intercellular communication by negatively regulating the release of exosomes. While its flippase activity towards membrane lipids and its role in membrane asymmetry remain to be confirmed, it is essential for maintaining neurite morphology and synaptic transmission.
ATP9A is also known as ATPIIA, NEDGBA.
