ATP2C1 : ATPase secretory pathway Ca2+ transporting 1
Description
The ATP2C1 (ATPase secretory pathway Ca2+ transporting 1) is a protein-coding gene located on chromosome 3.
The ATP2C1 gene provides instructions for making a protein called hSPCA1, which is an ATP-powered calcium pump. This protein uses energy from ATP molecules to transport calcium ions across cell membranes, specifically into the Golgi apparatus for storage. Proper calcium regulation is essential for various cell functions, including growth, division, movement, and adhesion. hSPCA1 also transports manganese ions into the Golgi, where it is required for protein processing. This protein is present throughout the body, with particular importance for keratinocytes, cells in the outer layer of skin. Calcium regulation in keratinocytes is crucial for maintaining the skin's barrier function, preventing the entry of foreign invaders.
ATP2C1 is an ATP-driven pump that transports Ca(2+) and Mn(2+) ions into the Golgi apparatus. It plays a crucial role in maintaining Ca(2+) homeostasis in the Golgi, regulating protein sorting and trafficking, and contributing to the structural integrity of the Golgi cisternae. ATP2C1 is essential for loading the Golgi with Ca(2+) in keratinocytes, contributing to their differentiation and the integrity of the epidermis. ATP2C1 also participates in the uptake of Ca(2+) and Mn(2+) into the Golgi of hippocampal neurons, impacting protein trafficking and neural polarity. Additionally, ATP2C1 may regulate Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol, potentially preventing cytotoxicity.
ATP2C1 is also known as ATP2C1A, BCPM, HHD, PMR1, SPCA1, hSPCA1.
