ATP2B3
Description
The ATP2B3 (ATPase plasma membrane Ca2+ transporting 3) is a protein-coding gene located on chromosome X.
ATP2B3 is a gene that encodes the Plasma membrane calcium-transporting ATPase 3 (PMCA3) enzyme. This enzyme belongs to a family of proteins that move calcium ions out of eukaryotic cells, working against a high concentration gradient. This is crucial for maintaining stable calcium levels within cells. PMCA3 is one of several isoforms of this enzyme, each with distinct functions based on their location in the body. Alternative splicing of ATP2B3 leads to different versions of the enzyme, further contributing to the diverse roles of PMCA3.
ATP2B3 is an ATP-driven calcium ion pump responsible for maintaining basal intracellular calcium levels specifically at the presynaptic terminals. It utilizes ATP to transport calcium ions from the cytosol across the plasma membrane into the extracellular space. There is evidence suggesting that ATP2B3 may also counter-transport protons, but the precise mechanism and stoichiometry of this calcium/proton exchange are yet to be determined.
ATP2B3 is also known as CFAP39, CLA2, OPCA, PMCA3, PMCA3a, SCAX1.
