ATP1B3
Description
The ATP1B3 (ATPase Na+/K+ transporting subunit beta 3) is a protein-coding gene located on chromosome 3.
ATP1B3, also known as CD298, is a gene that encodes for the Sodium/potassium-transporting ATPase subunit beta-3 enzyme in humans. This protein belongs to the Na+/K+ and H+/K+ ATPases beta chain family, specifically the Na+/K+ -ATPase subfamily. Na+/K+ -ATPase is a critical membrane protein responsible for establishing and maintaining the electrochemical gradients of sodium (Na+) and potassium (K+) ions across the cell membrane. These gradients are crucial for osmoregulation, the transport of various molecules, and the electrical excitability of nerve and muscle cells. This enzyme comprises two subunits: a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit plays a regulatory role by influencing the number of sodium pumps transported to the plasma membrane through the assembly of alpha/beta heterodimers. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes, and ATP1B3 encodes the beta 3 subunit. A pseudogene for ATP1B3 is located on chromosome 2.
ATP1B3 is also known as ATPB-3, CD298.
