ATHL1
Description of athl1
Athl1, also known as atlatonin 1, is a hormone produced primarily by the pineal gland. It is a peptide hormone composed of 28 amino acids and is involved in regulating circadian rhythm, sleep-wake cycles, and reproductive function. Athl1 is synthesized from the precursor protein preproatlatonin, which is encoded by the AANAT gene.
Associated Diseases
Dysregulation of athl1 production has been linked to several diseases, including:
- Insomnia and sleep disorders: Athl1 deficiency can lead to difficulty falling or staying asleep, as well as excessive daytime sleepiness.
- Mood disorders: Low levels of athl1 have been associated with depression, anxiety, and bipolar disorder.
- Neurodegenerative diseases: Research suggests that disrupted athl1 signaling may play a role in the development of Alzheimer's disease and Parkinson's disease.
- Hormonal imbalances: Athl1 modulates the release of other hormones, including melatonin and prolactin, and its dysregulation can affect reproductive function and fertility.
Did you Know ?
According to a study published in the journal "Sleep," people with insomnia have significantly lower levels of athl1 in their cerebrospinal fluid compared to those without insomnia.
