ATG13
Description
The ATG13 (autophagy related 13) is a protein-coding gene located on chromosome 11.
ATG13 is an autophagy-related protein essential for the formation of autophagosomes, which are critical for cellular degradation and recycling. It plays a key role in mitophagy, the selective removal of damaged mitochondria. ATG13 is a target of the TOR kinase signaling pathway, which regulates autophagy by controlling the phosphorylation status of ATG13 and ULK1, a key protein involved in autophagy initiation. ATG13 forms a complex with ULK1 and RB1CC1, which is essential for autophagosome formation. The regulation of ULK1 activity by ATG13 influences the kinase activity of mTORC1, a key regulator of cell growth and proliferation. ATG13 interacts with a variety of proteins, including ATG101, ULK1, ULK2, GABARAP, GABARAPL, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C, TAB2, TAB3, C9orf72, and RB1CC1. These interactions contribute to its diverse roles in autophagy and cellular processes.
ATG13 is a crucial autophagy factor involved in the formation of autophagosomes and mitophagy. It acts as a target of the TOR kinase signaling pathway, which controls autophagy by regulating the phosphorylation status of both ATG13 and ULK1, and by controlling the ATG13-ULK1-RB1CC1 complex. The regulation of ULK1 activity by ATG13 influences the kinase activity of mTORC1 and cell proliferation. (PMID:18936157, PMID:19211835, PMID:19225151, PMID:19287211, PMID:21795849, PMID:21855797)
ATG13 is also known as KIAA0652, PARATARG8.
Associated Diseases
- lysosomal storage disease
- prostate cancer
- Gollop-Wolfgang complex
- tibial hemimelia
- tibia, hypoplasia or aplasia of, with polydactyly
- fibular aplasia-ectrodactyly syndrome
- Blount disease
- metaphyseal anadysplasia
- acromesomelic dysplasia 2B
- brachydactyly-preaxial hallux varus syndrome
- acheiropody
- syndactyly type 4
