ATF5

Description

The ATF5 (activating transcription factor 5) is a protein-coding gene located on chromosome 19.

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene. ATF5 is a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family. ATF5 transcripts and protein are expressed in a wide variety of tissues, with particularly high expression in the liver. It is also present in a variety of tumor cell types. ATF5 expression is regulated at both the transcriptional and translational level. ATF5 is expressed in VZ and SVZ during brain development. The human ATF5 protein is made up of 282 amino acids. ATF5 is a transcription factor that contains a bZip domain. ATF5 has been shown to interact with DISC1 and TRIB3.

ATF5, also known as Activating transcription factor 5, is a transcription factor that regulates gene expression by binding to specific DNA sequences. It can both activate and repress gene transcription, depending on the target gene and cellular context. ATF5 binds to cAMP response element (CRE), ATF5-specific response element (ARE), and amino acid response element (AARE). It is crucial for various cellular processes, including survival, proliferation, and differentiation, often in a cell type-dependent manner. ATF5's activity is influenced by factors like CCND3, which enhances its transcription, and CDK4, which slightly inhibits it. ATF5 plays a significant role in brain development, promoting neuroprogenitor cell proliferation and preventing premature differentiation. It is also essential for the survival of mature olfactory sensory neurons and contributes to osteogenic differentiation. In liver cells, ATF5 participates in regulating the expression of CYP2B6, a drug-metabolizing enzyme, and acts as a negative regulator of the IL1B signaling pathway. Beyond its role as a transcription factor, ATF5 acts as a cofactor for CEBPB, promoting adipocyte differentiation. Moreover, ATF5 regulates centrosome dynamics, forming a ring-like structure around the mother centriole to control centrosome function and interaction with pericentriolar material. ATF5 interacts with various proteins, including CCND3, HSPA1A/HSPA1B, NPM1, NLK, alpha-tubulin, gamma-tubulin, PCNT, CEBPB, and EP300. These interactions play crucial roles in its stability, function, and regulation.

ATF5 is also known as ATFX, HMFN0395.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing