ATAD3B

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Description

The ATAD3B (ATPase family AAA domain containing 3B) is a protein-coding gene located on chromosome 1.

ATAD3B is potentially involved in shaping a unique mitochondrial network structure observed in stem cells. This structure is distinguished by reduced metabolic activity, lower amounts of mitochondrial DNA, and fragmented mitochondrial networks. ATAD3B may exert its influence by inhibiting the function of ATAD3A, interfering with its interactions with matrix nucleoid complexes.

ATAD3B is also known as AAA-TOB3, TOB3.

Associated Diseases

• hypertriglyceridemia 2
• cholesterol-ester transfer protein deficiency
• pancreatic triacylglycerol lipase deficiency
• thyroid hormone metabolism, abnormal, 2
• sitosterolemia
• homozygous familial hypercholesterolemia
• hyperlipoproteinemia type V
• hypercholesterolemia, autosomal dominant, 3
• hyperlipidemia due to hepatic triglyceride lipase deficiency
• hypercholesterolemia, autosomal dominant, type B
• chylomicron retention disease
• cancer
• breast cancer
• schizophrenia