ASTN2
Description
The ASTN2 (astrotactin 2) is a protein-coding gene located on chromosome 9.
Astrotactin-2, abbreviated ASTN2, is a protein involved in regulating cell adhesion during the migration of neurons in the developing brain. ASTN2 works in conjunction with its counterpart, ASTN1, to ensure proper neuron movement. While ASTN1 primarily functions as a receptor for glial guidance cues, ASTN2 plays a crucial role in recycling and transporting ASTN1 within the neuron. This recycling process is essential for maintaining the correct localization of ASTN1 at the front of the migrating neuron, enabling efficient movement along the glial fibers. ASTN2's interaction with specific lipids, particularly phosphoinositides, suggests it is recruited to membranes containing these lipids, potentially contributing to its role in ASTN1 trafficking.
ASTN2 is involved in the recycling of ASTN1, a neuronal cell adhesion molecule, to the front of the cell membrane during neuronal migration. It facilitates the internalization of ASTN1 and its movement within the cell. ASTN2 binds to specific lipids with phosphoinositide headgroups, suggesting its recruitment to these membranes.
ASTN2 is also known as bA67K19.1.
Associated Diseases
- Bardet-Biedl syndrome
- autosomal recessive limb-girdle muscular dystrophy type 2H
- autosomal recessive limb-girdle muscular dystrophy
- isolated asymptomatic elevation of creatine phosphokinase
- limb-girdle muscular dystrophy
- bipolar disorder
- major depressive disorder
- migraine disorder
